Movement disorder: a new study to identify genetic markers related to the occurrence of Parkinson's disease

September 27, 2019 / BIOON / -- researchers from Institute of neuroscience, University of Barcelona (ubneuro) and other institutions have recently identified a group of genetic variations related to the starting point of Parkinson's disease The results are published in the Journal of movement disorders, which will be able to define the research scope of new treatment targets and may have an impact on the diagnosis of the disease The study was led by Professor Maria Josep mart í and others Ubneuro researcher n ú RIA mart í n-flores was the first author of the paper, which was fully funded by the Parkinson's research foundation of the Michael J fox foundation in the United States (image source: www Pixabay Com) researchers studied the age at which genetic markers appear in Parkinson's disease "Known genetic markers, such as those of the synuclein gene, are associated with the onset of symptoms, but in this study, we focused on the effects of association of other markers that are not yet clear." Cristina malagelada, a researcher at ubneuro, said The results obtained from blood samples from more than 900 patients in the hospital clinic show that a group of mTOR metabolic pathway genetic markers combined to provide a good prediction of the onset age of Parkinson's disease Cristina malagelada stressed: "identification of these markers that interact and influence the onset of the disease can facilitate the study of new therapeutic targets in these candidate genes." According to UB researchers, the study, which uses biometrics, shows the importance of statistical interaction analysis in determining genetic associations because it can help explain complex diseases such as neurodegenerative diseases Parkinson's disease affects more than 1% of the population and is the second largest neurodegenerative disease after Alzheimer's disease According to the data of the World Health Organization (who), it affects 6 million people in the world, which may reach 12 million by 2030 Source of information: genetic markers linked to the start of symptoms of Parkinson's disease original source: rub é n fern á ndez ‐ Santiago et al, SNCA and mTOR pathway single nucleus otide polymers interact to modulate the age at onset of Parkinson's disease, movement disorders (2019) Doi: 10.1002/mds.27770