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    Home > Active Ingredient News > Study of Nervous System > Mov Disord: What are the immune characteristics of peripheral blood in patients with Parkinson's?

    Mov Disord: What are the immune characteristics of peripheral blood in patients with Parkinson's?

    • Last Update: 2021-08-14
    • Source: Internet
    • Author: User
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    Parkinson's disease (PD) is one of the most common neurodegenerative diseases, but its pathogenesis is still unclear
    .

    Current evidence shows that neuroinflammation is a major factor in the etiology and progression of Parkinson's disease neurodegenerative diseases
    .


    Neuroinflammation is not a simple response to neurodegeneration.


    immunity

    There is evidence that there is brain-peripheral interaction in PD, either through the glial-lymph pathway, or through the interference of the blood-brain barrier
    .

    In PD, there is brain-peripheral interaction, either through the glial-lymph pathway, or through the interference of the blood-brain barrier
    .


    In PD, there is brain-peripheral interaction, either through the glial-lymph pathway, or through the interference of the blood-brain barrier


    In the peripheral blood of PD patients, the number and quality of white blood cells and their subgroups have changed
    .


    The neutrophil-to-lymphocyte ratio (NLR) is a recognized indicator of the overall inflammatory state of the body


    This ratio integrates information about two white blood cell subpopulations and complementary immune pathways: neutrophils are involved in chronic inflammation, while lymphocytes may represent a regulatory pathway
    .


    It has been used as cancer, heart blood vessels prognostic factors and inflammatory diseases, Alzheimer's disease and cognitive impairment markers


    Heart blood vessels

    In this way, Laura Muñoz-Delgado and others of the Universitario Virgen del Rocío in Spain explored whether PD patients have a pro-inflammatory peripheral immune status compared with HCs
    .

    They first explored the difference in peripheral immune status between PD patients and HCs through a case-control study
    .

    Then, we explored whether NLR is related to the clinical features of PD
    .

    Finally, a meta-analysis was performed to clarify the role of NLR in PD
    .

    They found that in a case-control study, the NLR of PD patients was significantly higher than that of HCs (2.
    47 ± 1.
    1 vs.
    1.
    98 ± 0.
    91, P <0.
    001)
    .

    However, no association was found between NLR and age of onset, disease severity, or disease duration
    .

    However, no association was found between NLR and age of onset, disease severity, or disease duration
    .


    However, no association was found between NLR and age of onset, disease severity, or disease duration


    The important significance of this study lies in the discovery: Compared with HCs, the peripheral immune spectrum of PD patients has changed, and the NLR is higher
    .

    Compared with HCs, the peripheral immune spectrum of PD patients has changed, and the NLR is higher
    .


    Compared with HCs, the peripheral immune spectrum of PD patients has changed, and the NLR is higher


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