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Parkinson's disease (PD) is one of the most common neurodegenerative diseases, but its pathogenesis is still unclear
.
Current evidence shows that neuroinflammation is a major factor in the etiology and progression of Parkinson's disease neurodegenerative diseases
.
Neuroinflammation is not a simple response to neurodegeneration.
immunity
There is evidence that there is brain-peripheral interaction in PD, either through the glial-lymph pathway, or through the interference of the blood-brain barrier
.
.
In PD, there is brain-peripheral interaction, either through the glial-lymph pathway, or through the interference of the blood-brain barrier
In the peripheral blood of PD patients, the number and quality of white blood cells and their subgroups have changed
.
The neutrophil-to-lymphocyte ratio (NLR) is a recognized indicator of the overall inflammatory state of the body
This ratio integrates information about two white blood cell subpopulations and complementary immune pathways: neutrophils are involved in chronic inflammation, while lymphocytes may represent a regulatory pathway
.
It has been used as cancer, heart blood vessels prognostic factors and inflammatory diseases, Alzheimer's disease and cognitive impairment markers
Heart blood vessels
In this way, Laura Muñoz-Delgado and others of the Universitario Virgen del Rocío in Spain explored whether PD patients have a pro-inflammatory peripheral immune status compared with HCs
.
They first explored the difference in peripheral immune status between PD patients and HCs through a case-control study
.
Then, we explored whether NLR is related to the clinical features of PD
.
Finally, a meta-analysis was performed to clarify the role of NLR in PD
.
They found that in a case-control study, the NLR of PD patients was significantly higher than that of HCs (2.
47 ± 1.
1 vs.
1.
98 ± 0.
91, P <0.
001)
.
However, no association was found between NLR and age of onset, disease severity, or disease duration
.
.
However, no association was found between NLR and age of onset, disease severity, or disease duration
The important significance of this study lies in the discovery: Compared with HCs, the peripheral immune spectrum of PD patients has changed, and the NLR is higher
.
.
Compared with HCs, the peripheral immune spectrum of PD patients has changed, and the NLR is higher
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