Mov Disord: What are the changes in the brain structure at different stages of Parkinson's?

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease in the world
.

In addition to the main motor symptoms, patients may suffer from cognitive, neuropsychiatric, and autonomic dysfunction

Structural MRI of the brain allows non-invasive evaluation of cortical and subcortical morphology
.

Most imaging studies on PD report results consistent with the atrophy process that is the basis for neurodegeneration, such as the lower subcortical volume and cortical thickness of PD compared to healthy controls

In different studies, the reported atrophy patterns are different in terms of location and impact, and the relationship between the severity of the disease and abnormal brain morphology is still not well understood
.

The reported atrophy patterns vary in location and impact, and the relationship between the severity of the disease and abnormal brain morphology is still poorly understood
.

These differences may be partly caused by methodological factors, including the small sample sizes of individual studies and differences in analytical methods
.

Heterogeneity in the demographic and clinical characteristics of the patient sample, the areas of interest evaluated, and the algorithms used for segmentation and cancellation (for example, atlas-based versus voxel-based or vertex-based) may also produce differences in reported results, which in turn It also complicates the comparability of research results

The ENIGMA-PD working group is an international initiative to determine the pathological imaging characteristics of PD and the factors that affect them
.

The ENIGMA-PD working group is an international initiative to determine the pathological imaging characteristics of PD and the factors that affect them
.

In this way, Max A.
Laansma, MSc and others of the University of Amsterdam, in the largest study on PD brain morphology (ENIGMA) so far, explored the regional cortical thickness and cortical surface area between PD patients and healthy control subjects.
It also provides information about clinical morphology, taking into account the severity of the disease, age and gender, and the difference in subcortical volume
.

In this way, Max A.
Laansma, MSc and others of the University of Amsterdam, in the largest study on PD brain morphology (ENIGMA) so far, explored the regional cortical thickness and cortical surface area between PD patients and healthy control subjects.
It also provides information about clinical morphology, taking into account the severity of the disease, age and gender, and the difference in subcortical volume
.

They collected brain MRI and clinical data of 2,357 Parkinson's disease patients and 1182 healthy controls from 19 centers
.

The mixed effects model was used to analyze regional cortical thickness, cortical surface area, and subcortical volume

They found out
.

Compared with the control group, the patient showed thinner cortex in 38 of the 68 areas (dmax=-0.
20, dmin=-0.
09)

The patient showed thinner cortex in 38 of 68 areas (dmax=-0.

PD staging analysis shows that the initial manifestation is the thinning of the occipital, parietal, and temporal cortex, and as the severity of the disease increases, it extends to the cortical cortex area
.

The initial manifestation is that the cortex of the occipital lobe, parietal lobe, and temporal lobe becomes thinner, and as the severity of the disease increases, it extends to the cortical cortex area
.

The initial manifestation is that the cortex of the occipital lobe, parietal lobe, and temporal lobe becomes thinner, and as the severity of the disease increases, it extends to the cortical cortex area
.

From the second stage, the bilateral occipital lobes and amygdala continued to become smaller, and the difference between each increase was greater
.

Poor cognitive ability is related to extensive cortical thinning and smaller core edge structures
.

This research provides powerful and new imaging "signatures".
These features are usually incremental across regions in certain disease stages.
These results emphasize the importance of large-scale integration of multi-center data to explore diseases.
Sex
.

These characteristics are usually increased across regions in certain disease stages.
These results emphasize the importance of large-scale integration of multi-center data to explore diseases
.
These characteristics are usually increased across regions in certain disease stages.
These results emphasize the importance of large-scale integration of multi-center data to explore diseases
.

Original source:
Laansma MA, Bright JK, Al-Bachari S, et al.
International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.
Mov Disord.
Published online July 20, 2021:mds.
28706.
doi:10.
1002/mds.
28706

Original source:
Laansma MA, Bright JK, Al-Bachari S, et al.
International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease.
Mov Disord.
Published online July 20, 2021:mds.
28706.
doi:10.
1002/mds.
28706 Leave a message here