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Mov Disord: Parkinson's disease, ApoE may lead to the progression of dyskinesia

 Last Update: 2021-11-12
 Source: Internet
 Author: User

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Parkinson's disease (PD) is one of the most common neurodegenerative diseases, which is characterized by a wide range of clinical manifestations
.

The pathological feature of Parkinson's disease is the abnormal accumulation of α-synuclein (α-syn) in the substantia nigra

The APOE ε4 allele is the strongest risk factor for advanced Alzheimer's disease (AD), and it is known to be associated with amyloid β (Aβ) pathology
.

Previous studies have reported that APOE ε4 contributes to the early onset of PD dementia, but it has not been shown to be associated with the risk of PD development

In the Parkinson’s Disease Progression Markers Program, they obtained longitudinal data from 384 Parkinson’s disease patients who were divided into APOE ε4 carriers (n = 85) and non-carriers (n = 299)
.

Participants received an exercise assessment once a year during an average follow-up of 78.
9 months

Through subgroup analysis, we found that the effect of APOE ε4 was only significant in patients with high amyloid β burden (β = 0.
761, P <0.
001, 95% confidence interval: 0.
0356-1.
167)
.

The important significance of this study lies in the discovery: APOE ε4 may be related to the rapid movement of PD
.

APOE ε4 may be related to the rapid movement of PD
.

Original source:
Pu J, Jin C, Wang Z, et al.

Apolipoprotein E Genotype Contributes to Motor Progression in Parkinson's Disease .

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