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Mov Disord: Parkinson: Which proteins in cerebrospinal fluid affect the homeostasis of synuclein

 Last Update: 2021-08-14
 Source: Internet
 Author: User

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In most patients with α-synuclein diseases, such as Parkinson's disease (PD) and Lewy body dementia (DLB), the common pathological feature is the accumulation of abnormal conformations of α-synuclein
.

Subsequently, several molecular pathways related to the homeostasis of α-synuclein protein were discovered in genetic research and cell and animal models
.

These pathways include impaired autophagy, such as endolysosomal dysfunction, ubiquitin-proteasome system, mitochondrial homeostasis, and synaptic plasticity

However, there is a lack of effective biomarkers, which are clearly disease and/or pathway specific in human biological fluids

(3) The CSF level of these proteins is positively correlated with the CSF level of total alpha-synuclein, that is, those proteins with low protein homeostasis have lower content and are related to the low level of total alpha-synuclein
.

(4) These findings can be confirmed longitudinally
.

Compared with PD patients with a normal protease profile, PD patients with a low CSF protease profile show lower levels of α-synuclein in the longitudinal direction

The important significance of this research lies in the discovery: CSF protein related to neurotransmitter secretion, synaptic plasticity, and endolysosomal autophagy may be used as a organism related to the homeostasis of α-synucleotide protein in PD and DLB Markers
.

Original source:

The CSF protein related to neurotransmitter secretion, synaptic plasticity and endolysosomal autophagy may be used as a biomarker related to the homeostasis of α-synucleotide protein in PD and DLB
.
The CSF protein related to neurotransmitter secretion, synaptic plasticity and endolysosomal autophagy may be used as a biomarker related to the homeostasis of α-synucleotide protein in PD and DLB
.
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