Mov Disord: Is it possible to suffer from Parkinson's, check glutathione and take a look

The reduction of glutathione (GSH) is considered to be one of the earliest biochemical changes in Parkinson's disease
.

Autopsy studies have shown that GSH is lacking in the substantia nigra (SN) of patients with Parkinson's disease or incidental Lewy body disease (ILBD), and there is substantial evidence to support GSH interference in the clinical stage of PD

Nikolaos Scarmeas et al .
explored the potential role of plasma glutathione as a precursor PD (pPD) risk/susceptibility biomarker by detecting the longitudinal correlation between plasma glutathione (GSH) and the probability trajectory of pPD
.

Nikolaos Scarmeas et al .
explored the potential role of plasma glutathione as a precursor PD (pPD) risk/susceptibility biomarker by detecting the longitudinal correlation between plasma glutathione (GSH) and the probability trajectory of pPD
.

The research team followed up a total of 405 community residents (median age [interquartile range] = 73.
2 [7.
41] years), the average follow-up time (standard deviation) was 3.
0 (0.
9) years, no Parkinson's disease clinical Features
.

For every increase of 1 μmol/L in plasma GSH, the incidence of pPD decreased by 0.
4% during the 1-year follow-up (95% confidence interval [CI], 0.
1%-0.
7%; P = 0.
017)
.

For every increase of 1 μmol/L in plasma GSH, the incidence of pPD decreased by 0.
4% during the 1-year follow-up (95% confidence interval [CI], 0.
1%-0.
7%; P = 0.
017)
.

Compared with the participants with the lowest glutathione levels, the participants in the top tertile of glutathione had a 12.
9% slower increase in the probability of pPD during the 1-year follow-up
.

Compared with the participants with the lowest glutathione levels, the participants in the top tertile of glutathione had a 12.
9% slower increase in the probability of pPD during the 1-year follow-up
.

In summary, the plasma glutathione concentration is related to the pPD probability trajectory, and a lower concentration predicts that pPD may increase
.

Current research results indicate that plasma glutathione may help identify individuals who may reach the diagnostic threshold of pPD more quickly

In summary, the plasma glutathione concentration is related to the pPD probability trajectory, and a lower concentration predicts that pPD may increase

Plasma Glutathione and Prodromal Parkinson's Disease Probability [published online ahead of print, 2021 Oct 25].

Plasma Glutathione and Prodromal Parkinson's Disease Probability [published online ahead of print, 2021 Oct 25].
Mov Disord.
2021;10.
1002/mds.
28826.
doi:10.
1002/mds.
28826 Plasma Glutathione and Prodromal Parkinson's Disease Probability [published online ahead of print .
, 2021 Oct 25] Mov Disord 2021; 10.
1002 / mds.
28826 doi:.
.
10.
1002 / mds.
28826 in this message