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The APOE ε4 allele is the strongest risk factor for late-onset Alzheimer's disease (AD) and is known to be associated with amyloid β (Aβ) pathology
.
Previous studies have reported that APOEε4 contributes to the onset of early dementia in PD, but has nothing to do with the risk of PD
The APOE ε4 allele is the strongest risk factor for late-onset Alzheimer's disease (AD) and is known to be associated with amyloid β (Aβ) pathology
Bao-Rong Zhang et al .
The study obtained longitudinal data from 384 PD patients who were divided into APOE ε4 carriers (n = 85) and non-carriers in the Parkinson’s Disease Progression Marker Initiative (n = 299)
.
Participants received an exercise assessment once a year, and the average follow-up time was 78.
The study obtained longitudinal data from 384 PD patients who were divided into APOE ε4 carriers (n = 85) and non-carriers in the Parkinson’s Disease Progression Marker Initiative (n = 299)
The movement progress of PD patients with APOE ε4 was significantly faster than that of non-carriers (β = 0.
283, P = 0.
026, 95% confidence interval: 0.
033–0.
532)
.
Subgroup analysis found that the effect of APOE ε4 was only significant in patients with high amyloid β load (β = 0.
The movement progress of PD patients with APOE ε4 was significantly faster than that of non-carriers (β = 0.
The longitudinal trajectory of the third part of the Dyskinesia Social Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) showed that the APOE ε4 positive group progressed faster
.
The gender is fixed as male
The longitudinal trajectory of the third part of the Dyskinesia Social Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) showed that the APOE ε4 positive group progressed faster
The results of this study showed that the APOE ε4 allele is related to the rapid movement progression of PD patients
Original source
Pu, J.
Pu, J.
-L.
et al.
Apolipoprotein E genotype contributes to motor progression in Parkinson ’s disease.
Mov.
Disord.
Pu, J.
-L.
et al.
Apolipoprotein E genotype contributes to motor progression in Parkinson 's disease.
Mov.
Disord.
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