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Figure 1 Schematic diagram of the action of the developer: a) Schematic diagram of the interaction between AuNS-1 and AuNS-2; 2) The photoacoustic wavelength of the aggregate is red-shifted compared to the monomer
Figure 2 Characterization of developer in three environments (without MMP-9, with MMP-9, with BSA): a) solution color change; b) absorption wavelength change; c) average particle size (value); d) particle size Diameter (TEM)
Subsequently, the authors confirmed the feasibility of this method both in vitro and in vivo through cell culture and transplantation of breast cancer mouse models, respectively
Figure 3 In vitro signals obtained with ultrasound (US), photoacoustic (PA) and combined (US/PA), respectively
Fig.
Conclusion: The authors successfully improved the targeting of imaging agents in the tumor microenvironment using DNA ligands
references
[1] Jinhwan Kim, Anthony M.
American PhotoSound Small Animal 3D Photoacoustic/Fluorescence Imaging System (PAFT)
The American PhotoSound Small Animal Whole Body 3D Photoacoustic/Fluorescence Imaging System (PAFT) provides a complete solution for in vivo imaging and characterization of small animals
It can realize near-infrared region one and near-infrared region two (670-2600 nm) mouse whole body 3D photoacoustic/fluorescence imaging system, using OPO tunable laser, providing 670-2600 nm continuous pulse laser, complete 3D photoacoustic imaging (with Full 3D imaging with 100 um isotropic resolution, non-slice stack imaging), high throughput (256 electron channels), high sensitivity (60 nM ICG), desktop design, easy to use, fast imaging (complete one 3D scan) 30 seconds)
Past recommendations:
● Photoacoustic imaging material | tumor microenvironment-activated photoacoustic imaging contrast agent
● American PhotoSound Small Animal Whole Body 3D Photoacoustic/Fluorescence Imaging System
● Mouse Anatomy Application Notes - American PhotoSound Small Animal Whole Body 3D Photoacoustic/Fluorescence Imaging System
● Photoacoustic Imaging Applications | Exploring Atherosclerotic Plaques
