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Researchers have discovered that a unique type of macrophage, an immune cell that clears out bacteria or dead cells, plays a key role in chronic inflammation and scarring in the lungs and skin of people with scleroderma (systemic sclerosis)
The research team injected mice with biodegradable PLG nanoparticles, or poly(lactic-glycolic acid) for short
"The findings revealed a stark difference: The untreated mice had horrific scarring in their lungs, while the mice treated with the nanoparticles had severe disease worsening or disappeared completely," said the paper's senior author, Michigan Rheumatology said John Varga, MD, director of the Division of Disease Medicine
The team believes that MARCO+ cells are activated in scleroderma patients and circulate in the bloodstream, entering tissues and causing scarring
PLG has been approved by the U.
"We hope this therapy will one day be evaluated in clinical trials for scleroderma," Varga said
Journal Reference :
Dan Xu, Swati Bhattacharyya, Wenxia Wang, Igal Ifergan, Ming-Yi Alice Chiang Wong, Daniele Procissi, Anjana Yeldandi, Swarna Bale, Roberta G.
