Motherwort is effective in treating cerebral apoplexy

The team led by Professor Zhu Yizhun, Dean of Fudan University School of medicine, after more than five years of research, found that Leonurus alkaloids extracted from Leonurus heterophyllus had obvious curative effect on treating cerebral apoplexy: it can significantly reduce the infarct area of cerebral cortex caused by cerebral ischemia, and improve the symptoms of neurological deficit At present, this project has been incubated as a national first-class new drug candidate on the national major new drug creation platform, and its research results have been published in the latest international stroke research authoritative journal stroke Motherwort has the effect of improving blood circulation, promoting blood circulation and removing blood stasis It is a traditional gynecological medicine But for a long time, due to the high cost and heavy workload of extracting the effective compounds from Leonurus, the scientific value of its monomer has not been fully explored Professor Zhu Yizhun was inspired by the unique effect of Leonurus japonicus on improving blood circulation He led the research team to explore a new synthesis route and amplification process After more than five years of unremitting efforts, he finally successfully extracted the effective monomer compound Leonurus japonicus alkaloid from Leonurus japonicus and named it "scm-198" Zhu Yizhen and his team's research found that under the condition of disease, such as ischemia and hypoxia, the "mitochondria", one of the basic elements of complete cells, will swell, causing cell rupture, leading to brain tissue necrosis and myocardial necrosis, and finally death The study also found that ATP in human body is the energy to provide normal life activities of cells, and it is also the direct source of energy needed for the activities of cells in vivo When cells are lack of oxygen, the energy activity of ATP will also be reduced, leading to apoptosis The mechanism of action of Leonurus japonicus scm-198 is to reduce the oxygen consumption of brain cells, inhibit the cell death caused by mitochondrial oxidative stress reaction, activate the activity of adenosine triphosphate, prevent the further necrosis and apoptosis of cells, so as to achieve the purpose of reducing brain tissue necrosis According to the Journal of stroke, the successful development of scm-198 may make the effective monomer compound in Leonurus japonicus become a new drug in the future clinical treatment of stroke.