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Can a protein in a mosquito give us a better understanding of how our brain works? Professor Ofer Yizhar from the Department of Neurobiology of the Weizmann Institute of Science and his team extracted a light-sensitive protein from mosquitoes and used it to design an improved method to study the information transmitted between neurons in the mouse brain
Izar and his laboratory team have developed so-called optogenetic methods—research techniques that allow them to “reverse engineer” the activity of specific brain circuits in the brain to better understand their functions
Although optogenetic methods have achieved some breakthrough results in laboratories around the world in recent years, they may be a bit fussy
Yizhar and his large group of students, including Dr.
The results proved that mosquito rhodopsin is the most suitable
More importantly: Unlike traditional drugs that affect multiple parts of the brain and are difficult to control, the researchers found that because only neurons that produce mosquito sensors are affected by light, the regulation of brain synapses can be affected in space and time.
Journal Reference :
Mathias Mahn, Inbar Saraf-Sinik, Pritish Patil, Mauro Pulin, Eyal Bitton, Nikolaos Karalis, Felicitas Bruentgens, Shaked Palgi, Asaf Gat, Julien Dine, Jonas Wietek, Ido Davidi, Rivka Levy, Anna Litvin, Fangmin Zhou, Kathrin Sauter, Peter Soba, Dietmar Schmitz, Andreas Lüthi, Benjamin R.
