More and more forgetful? It may be related to a lack of an important protein

Synapses are responsible for information transmission between neurons Local regulation of synaptic function is very important for the formation of neural network and memory Although some studies have shown that the overall translation disorder can affect the long-term memory of mice, the local translation regulation affected by RNA particles remains to be studied Rng105 is a factor involved in local synaptic protein synthesis In this new study, the team demonstrated the effect of rng105 on long-term memory building in mice The loss of rng105 can affect the synaptic strength and structural plasticity of hippocampal neurons in mice In addition, the absence of rng105 in the brain or hippocampus of mice seriously affects the long-term memory formation in spatial and situational learning tasks The results of genome-wide analysis of mRNA distribution in hippocampus showed that the lack of rng105 damaged the asymmetric cellular dendritic localization of local mRNA For long-term memory formation, the elongation of synaptic structures between neurons and the maintenance of new neural circuits (known as synaptic enhancement) are essential However, the synaptic enhancement in mice without rng105 was no longer sustained The researchers also found that rng105 regulates protein synthesis involved in the correct localization of AMPA receptors on synapses, which are known to be related to memory Lack of rng105 reduced the dendritic localization of mRNA encoding the AMPAR surface expression regulator "We are working to expand long-term memory research with a view to improving long-term memory in patients with human diseases," Dr Shiina said Rng105 may be a key factor in improving the long-term memory ability of patients