Molecular Psychiatry: A common pattern of functional vulnerability associated with emotion processing in the frontotemporal lobar degeneration spectrum

Among social cognitive functions, perception of social stimuli is a highly developed skill that gathers important information for interpersonal interactio.

Among social cognitive functions, perception of social stimuli is a highly developed skill that gathers important information for interpersonal interactio.

Elisa Canu Elisa Canu et al investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) in brain networks in frontotemporal lobar degeneration (FTL.

Eighty patients with FTLD (including behavioral variant frontotemporal dementia, primary progressive aphasia, progressive supranuclear palsy syndrome, motor neuron disease) and 65 healthy controls underwent resting-state functional M.

Eighty patients with FTLD (including behavioral variant frontotemporal dementia, primary progressive aphasia, progressive supranuclear palsy syndrome, motor neuron disease) and 65 healthy controls underwent resting-state functional M.

The main findings of the study are:

FTLD patients had morbid CATS scores compared to contro.

FTLD patients had morbid CATS scores compared to contro.

In the control group, increased rs-FC of the cerebellum and visual associative network were associated with better scores on emotion matching and discrimination tasks, respectively; whereas decreased rs-FC of the visuospatial network was associated with better performance in emotional matching and nami.

FigureThe relationship between resting-state functional connectivity and CATS scores in healthy controls

FigureThe relationship between resting-state functional connectivity and CATS scores in healthy controls

In FTLD, the association between rs-FC and CATS scores involved more brain regions , such as the orbitofrontal and middle frontal gyrus of anterior networks .

In FTLD, the association between rs-FC and CATS scores In FTLD, the association between rs-FC and CATS scores involves more brain regions ,.

FigurePositive correlation between resting-state functional connectivity and CAT scores in patients with FT.

FigurePositive correlation between resting-state functional connectivity and CAT scores in patients with FT.

FigureResting-state functional connectivity is inversely correlated with CAT scores in FTLD patien.

FigureResting-state functional connectivity is inversely correlated with CAT scores in FTLD patien.

FigurePost hoc functional connectivity analysis (cluster-base.

FigurePost hoc functional connectivity analysis (cluster-base.

Changes in Rs-FC associated with CATS were similar in all FTLD group.

Emotion-processing-related rs-FC patterns involved more brain regions in FTLD than controls, likely due to loss of function-specificity and compensatory attempt.

These associations were similar across all FTLD groups, suggesting that emotional processing disorders share common pathophysiological mechanisms across the FTLD spectrum, regardless of clinical presentation and atrophy pattern.

Taken together, affective processing dysfunction is present across the entire FTLD spectr.

The CATS paradigm provides a screening tool for detecting early emotion processing changes in each FTLD varia.

The relationship between emotional processing and functional brain connectivity differs between FTLD patients and healthy controls, with the former showing a large number of connections stemming from neurospecific loss and compensatory attemp.

These associations, consisting primarily of frontal networks, basal ganglia, and motor observation circuits, are shared across all FTLD cases , regardless of clinical presentation, genetic status, and pattern of GM injury, suggesting that across the FTLD spectrum, there is a Common functional vulnerability patterns related to emotion processing

The relevance of the current work lies in its potential impact on the clinical setting and the field of resear.

In all FTLD cases, not only in bvFTD, having information on emotion recognition failures can support clinical diagnosis and predict patient outcom.

In addition, this study, which includes behavioral and image data, will help improve the understanding of neural networks underlying emotion processing in aging and neurodegenerative diseas.

Behavioral interventions can target brain regions that preserve function (at least in the early stages of the diseas.

Taken together, affective processing dysfunction is present across the entire FTLD spectr.

The CATS paradigm provides a screening tool for detecting early emotion processing changes in each FTLD varia.

The relationship between emotional processing and functional brain connectivity differs between FTLD patients and healthy controls, with the former showing a large number of connections stemming from neurospecific loss and compensatory attemp.

These associations mainly include frontal networks, basal ganglia, and action observation circui.

The relationship between emotion processing and brain functional connectivity differs between FTLD patients and healthy controls, with the former showing a large number of connections that originate from neural-specific Loss and Compensation Attemp.

These associations are shared across all FTLD cases , irrespective of clinical presentation, genetic status, and pattern of GM impairment, suggesting that across the FTLD spectrum, there is an association with emotion processing Common functional vulnerability patterns associated with emotion processing across the FTLD linea.

The relevance of the current work lies in its potential impact on the clinical setting and the field of resear.

In all FTLD cases, not only in bvFTD, having information on emotion recognition failures can support clinical diagnosis and predict patient outcom.

In addition, this study, which includes behavioral and image data, will help improve the understanding of neural networks underlying emotion processing in aging and neurodegenerative diseas.

Behavioral interventions can target brain regions that preserve function (at least in the early stages of the diseas.

diagnosis

original source

original source

Canu,.

, Calderaro,.

, Castelnovo,.

et .

Resting state functional brain networks associated with emotion processing in frontotemporal lobar degenerati.

Mol Psychiatry(202
https://d.

org/11038/s41380-022 -01612-9

Canu,.

, Calderaro,.

, Castelnovo,.

et .

Mol Psychiatry https://d.

org/11038/s41380-022-01612-9

 

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