Mol omics: a new opinion on immune enteritis

December 12, 2019 / BIOON / -- as we all know, intestinal diseases are usually difficult to diagnose, however, we can try to use computational methods to deepen understanding, rather than trying to understand individual symptoms or the role of a single gene Recently, korcsmaros organization has created a research and development pipeline combining experiment and calculation, so as to reveal which genes are important "major regulatory factors" in intestinal tract and which genes overlap with IBD related genes, which provides a new perspective for research in IBD (image source: www Pixabay Com) to achieve this vision, we need to observe the cells in the gut to a large extent Paneth cells release antimicrobial peptides to protect the intestine from pathogens, while goblet cells release mucus to form a protective barrier Its dysfunction is related to IBD and other diseases Recently, a model called "organ like" has been developed by culturing stem cells from mice or patients to make intestinal models, and then exploring the effects of different therapies, thus opening up the way of precision medicine They can also be modified to study the relative importance of different cell types in the system and to explore the interaction between different genes in healthy or diseased cells "Based on our transcriptome analysis, we see a significant increase in targeted cell types, as we would expect when using organ like cells," said Dr Agatha treveil, the study's author The results were published in the journal Molecular omics In essence, we can tag genes that regulate other genes - especially those that regulate many processes, which are important for the function of goblet cells and Paneth cells Many of these genes are involved in both inflammation and IBD, which not only confirms the important role of Paneth cells in IBD, but also opens up another way to understand the disease "This is a pioneering step in building a pipeline to better understand the genetic networks that work in the gut," said Agatha treveil This allows us to design new experiments to further explore the processes associated with IBD " Source of information: gutfeeling: a network approach towards understanding IBD source: a treveil, P Sudhakar, Z J Matthews, t wrzesi ń ski, e J Jones, J Brooks, M Ö lbei, i hautefort, L J hall, S R carding, U Mayer, P Powell, t wileman, F Di Palma, W haerty, T Korcsmáros Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approaches Molecular Omics , 2020; DOI: 10.1039/c9mo00130a