Mol Gey: British scientists have discovered Alzheimer's inhibitory genes and developed a fast-track drug testing platform.

!---- Alzheimer's disease is one of the most common types of dementia in old age and one of the most common chronic diseases in old age, the introductionevery three seconds there is an increase in the number of People with Alzheimer's disease worldwide, with 5-8 out of every 100 people aged 60 and overthe cause of the disease is still unclear, and British scientists have discovered an Alzheimer's suppressive gene and developed a fast-track drug testing platformDown syndrome (DS), or 21-tri-body syndrome, is caused by chromosomal abnormalities (one more chromosome 21) that causes about 70 percent of a person's life to develop Alzheimer's diseasethis is because the extra chromosome 21 they carry contains a gene for amyloid precursor proteins that cause early Alzheimer's disease when overexpressed or mutateda study of the chromosomes of people with Down syndrome, researchers in the Uk have found a gene that naturally inhibits the symptoms of Alzheimer's disease in human brain cellsthey have also developed a new drug rapid screening system to find potential treatments to delay or prevent the diseasethe study, led by Professor Dean Nizetic of Queen Mary University of London, published in the journal Nature's Molecular Psychiatry on 10 July, entitled "Patient-Alzheimer specific-pathology in trisomy 21 cerebral In the study, researchers collected hair cells from patients with Down syndrome and reprogrammed them to make them stem cells, which were then directed into brain cells in a petri dishin these brain-like cells, the researchers observed rapid pathological developments similar to Alzheimer's disease, including the iconic triple of Alzheimer's advances - amyloid plaque lesions, progressive neuronal death, and abnormal build-up of tau proteins in neuronsLead researcher Professor Dean Nizetic,, said: "Because this is the first cell-based system in this study, it has all three pathological characteristics of Alzheimer's disease and does not have any overexpression of artificial genesthe system opens up prospects for screening new drugs that can delay or even prevent Alzheimer's disease" then, the researchers showed that the system could serve as a platform for early preventive drug testingthey selected two drugs known to inhibit beta-amyloid protein generation and tested them on these brain cells, and within six weeks they were shown to prevent the onset of Alzheimer's diseaseAlthough the two special drugs failed clinical trials for other reasons and were not suitable for Alzheimer's disease, the team further demonstrated the principle that the system could be used to screen any drug and demonstrated the potential for further research within six weeksimportant, the team found evidence of the existence of a naturally functioning Alzheimer's suppressive gene (BACE2 gene)acts in a similar way to cancer-suppressing genes, which increase their activity and help prevent/slow Alzheimer's disease in human brain tissue and may in the future act as a biomarker to determine people's risk of developing the disease, or by enhancing its role as a new treatment Professor Dean Nizetic, , explained: "Although it is still in its early stages, the system offers theoretical possibilities for further development as a tool for predicting who might develop Alzheimer's disease the same stem cell process can be used in anyone's hair follicles to see if the resulting brain cells develop symptoms of Alzheimer's disease in a petri dish the goal is to use cell-based systems to identify people at higher risk of early disease and to consider the possibility of individual disease prevention before they enter the brain we are a long way from achieving that goal Professor John Hardy, from University College London, added: "I think we now have the potential to develop a new model of human disease, which will be a big step forward "