Mol G. : Shocked! Fish oil may help treat depression!

, June 28, 2020 --
BioValley
BIOON /PRNewswire/ -- Adultstem cellfrom patient-sourced sources can be used to simulatedepression and test patients' responses to drugs, according to a study published in Molecularyresearchers at the University of Illinois at Chicago (UIC) used clinicaldiagnosisstem cellfor adultsdepression, and found that fish oil produced an antidepressant response when tested in a modelUIC's Mark Rasenick, who is the lead researcher on the study, said the study offers many new findings that could help scientists better understand how the brain works and why some people respond to depression with medication, while others benefit from antidepressants with limited benefitsPicture Source:"It'
s also exciting to find that fish oil -- an easily available natural product -- may be the scientific evidence of effective drugs fordepression," said Rasenick, a distinguished professor of physiology, biophysics and psychiatry at the UIC School of Medicine severe depressive disorder, or depression , is the most common mental illness About one in six people experience depression at least once in their lifetime However, about one-third of patients failed to treat antidepressants in the study, UIC researchers used skin cells in adults with depression, which were converted into stem cells at Massachusetts General Hospital and then guided into nerve cells Skin biopsy samples were taken from two types of patients: those who responded to antidepressants and those who were resistant to antidepressants when testing fish oil, both the treatment of sensitive patients and the model of patients who are treated with intolerance respond Rasenick says the response is similar to prescription antidepressants, but it is produced through different mechanisms "We found that fish oil acts to some extent on glial cells, not neurons," Rasenick said For years, scientists have paid little attention to glial cells -- a type of brain cell that surrounds nerve cells -- but there is growing evidence that glial cells may play a role in depression Our research shows that glial is also important for antidepressants "Our study also shows that stem cell models can be used to study responses to treatments, and that fish oil as a treatment or as an auxiliary treatment, and further research into depression is worthwhile," said Rasenick " (BioValleyBioon.com) References: Jiang-Zhou Yu et al, N-3 polyunsaturated fatty acids promot astrocyte and neurotrophin production no nocamp in patient-derived stem cells Molecular, Prosy (2020) DOI: 10.1038/s41380-020-0786-5