-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Editor-in-charge | Xi
Innate nucleic acids sensing (INAS) is an important way for the body to sense microbial invasion and self-tissue damage, which is essential
for host cells to resist foreign microbial infection and maintain homeostasis.
Glucose is the main source of energy for organisms to maintain normal life activities, and it is also an important medium
for body cells to perceive environmental changes.
Recent studies have also found that hyperglycemia and diabetes are closely
related to susceptibility to microbial infections, including coronavirus infection.
But little is known about how the body integrates information about glucose levels and thus regulates host immunity
.
On November 15, 2022, Xu Pinglong's laboratory at the Institute of Life Sciences of Zhejiang University published an online report entitled AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity online on Molecular Cell work
.
This study is the first to report the physiological phenomenon of rapid decline in blood glucose level in the very early stage of viral infection, which leads to significant activation of AMPK, the core molecule of glycolipid metabolism, identifies TBK1, the natural key immune kinase, as the direct substrate of AMPK, and reveals the exquisite mechanism
of the body's dual perception of nucleic acid and glucose molecular levels through the AMPK-TBK1 signaling axis.
The protein kinase AMPK is the body's main energy and glucose abundance sensor, which recognizes and modifies specific amino acid sequence patterns, phosphorylates a variety of substrate molecules, and thus regulates the body's carbohydrates, lipids and other metabolic processes, maintaining cellular energy, oxidation levels and nutrient balance
.
The researchers initially found an interesting phenomenon in rodent virus models that different types of viral infections can induce rapid and sharp drops in blood sugar levels in many rodents, and thus lead to significant activation
of AMPK in tissues and organs.
Subsequent studies demonstrated that AMPK was able to directly recognize the classical substrate motif of the TBK1 protein and efficiently phosphorylate its 511-position serine, thereby promoting TBK1 activation, TBK1-IRF3 interaction, and assembly of MAVS and STING signaling complexes, thereby significantly promoting innate immune responses and antiviral host defenses
。 Therefore, targeted knock-in mice and cells that reduce glucose levels, activate AMPK, or mimic AMPK-modified TBK1 genes exhibit a hypersensitive innate immune response, while inhibition or blocking AMPK-TBK1 signaling leads to the loss of innate immune recognition and response
to viral infection.
This work discovered the function of the body to regulate infection immunity through controlled blood glucose levels, revealed that TBK1 is the direct substrate of AMPK, and proposed a dual sensing mechanism
of body danger signal-energy signal.
These new findings demonstrate the intrinsic molecular connection between glycolipid metabolism and natural immune response, which is an important expansion of research in the field of immunometabolism, and also provides a theoretical and experimental basis
for targeting AMPK to control immune response.
Dr.
Qian Zhang, Dr.
Shengduo Liu and Professor Chensong Zhang of Xiamen University are co-first authors of the paper, and Professor Xu Pinglong is the corresponding author.
The research work has been strongly supported
by Professor Lin Shengcai, Professor Feng Xinhua, Professor Liang Tingbo, Professor Huang Yaowei and other collaborators.
The body's blood glucose level regulates nucleic acid recognition and infection immune response
through the AMPK-TBK1 signaling mechanism Xu Pinglong's laboratory uses interdisciplinary research technology system, has long been engaged in the research of the signaling mechanism, regulation and physiological and pathological function of natural immune recognition, and has made systematic contributions to the cellular and pathological functions, new signaling mechanisms and regulatory mechanisms of nucleic acid immune recognition, and the research work has been published in Nature Cell Biology (2022, 2019, 2017), Molecular Cell (2022, 2021, 2020, 2014), Cell Host & Microbe, Genes & Development and other well-known academic journals, and funded by many funds such as National Outstanding Youth and so on
.
Due to the needs of research expansion, 2-3 postdoctoral fellows (or researchers) in the fields of metabolism, neurology, pathology, infection immunity, cell engineering, biomaterials, viruses, bioinformatics, pharmacy and other fields are recruited
.
Job requirements: strong interest in scientific exploration and innovative thinking, strong independent scientific research work ability and English writing ability, full of team spirit
.
The laboratory provides an excellent working environment, scientific research platform and competitive salary
.
Resume delivery (if you are interested, please send your resume and 1-2 published representative works to): https://jinshuju.
net/f/ZqXwZt or scan the QR code Submit the original link of the resume
: https://doi.
org/10.
1016/j.
molcel.
2022.
10.
026
Platemaker: Eleven
Reprint instructions
【Non-original article】The copyright of this article belongs to the author of the article, welcome to forward and share, reprinting is prohibited without the permission of the author, the author has all legal rights, violators will be investigated
.
