Mol Cell: For the first time, a complete image of all communication paths in human cells infected with SARS-CoV-2 is expected to help develop a new type of targeted COVID-19 therapy.

September 10, 2020 // -- Phosphate groups may play an important bio-chemical role in intracellular signaling processes (e.g., stimulating cell growth or inducing cell metabolism), where phosphate groups usually absorb protein proteins or are removed to control protein activity, in which a change in protein induces a series of changes in cascading signals, usually targeting the nucleus, which can be turned on or off in the nucleus.
Photo Source: Pixabay/CC0 Public Domain In a recent study published in the international journal Molecular Cell, scientists from the University of Gothenford and others successfully mapped the full picture of all communication paths in human cells infected with SARS-CoV-2 for the first time and observed changes in these infection triggers; Analysis of all proteins carrying phosphate groups at a particular point, i.e. phospholipproroteome, revealed that SARS-CoV-2 was able to significantly utilize all the signaling path paths in the host cell, the growth signaling path from the outside of the cell to the inside of the cell, and if these signaling paths were interrupted, the virus could no longer replicate.
researcher Christian Münch explains that the growth factor's signaling pathline can be precisely blocked at a certain point, i.e. when the extracellular signal reaches the growth factor recipient signaling receiver, however, there are some very effective cancer drugs that slightly block the growth factor signaling path in the cascading reaction, through which different growth factor recipient signals are blocked, and now researchers have tested five of these substances in the cells, which are perfectly capable of blocking SARS-CoV-2 replication. In the
article, the researchers conducted experiments in laboratory-cultured cells, which meant that the results might not be translated into human body studies without late-stage in-depth trials, but by testing other infectious viruses, the researchers found that viruses often alter signaling path paths in human host cells, which are critical to virus replication, while approved drugs may have a huge lead in development and could soon begin clinical research.
Researchers have patented a new method that uses special inhibitors to interfere with cell signaling paths to treat COVID-19 infections, and later researchers will continue to delve deeper into how to effectively inhibit sars-CoV-2 infection and transmission by blocking signaling path paths in cells.
origins: Kevin Klann, Denisa Bojkova, Georg Tascher, et al. Growth factor receptor signaling investment prevents SARS-CoV-2 replication, Molecular Cell (2020). doi:10.1016/j.molcel.2020.08.006.