MMR: Prof. Yi's team elucidated a new molecular mechanism for the malignant progression of esophageal cancer

Recently, the team of Professor Hu Yi, director of the Department of Oncology Medicine of the Fifth Medical Center of the PLA General Hospital, and the team of Professor Yan Xiaolong of the Second Affiliated Hospital of the Air Force Military Medical University published a report entitled "Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive" in the international academic journal Military Medical Research Feedback loop and suppressing the USP10-maintained HDAC7 protein stability" research paper

Professor Hu Yi and Professor Yan Xiaolong of Air Force Military Medical University are co-corresponding authors of this paper, and Ma Zhiqiang, attending physician of the Department of Oncology Medicine, and Dr.

Military Medical Research Journal (Impact Factor: 34.

Melatonin is a hormone secreted primarily by the pineal gland and has been shown to have a wide range of biological activities, including circadian regulation, antioxidant, anti-inflammatory, and immunomodulating

To explore the role of melatonin treatment on ESCC cell growth, we performed colony formation and EdU incorporation assays to analyze the proliferative activity

The prognostic effect of HDAC7 expression in ESCC has not been reported

According to the latest data from the National Cancer Center in 2022, in China, there are 253,000 new cases of esophageal cancer in the year, and the annual number of deaths has reached 194,000, so the treatment of advanced esophageal cancer is currently a major clinical problem, Professor Hu Yi's team has long been committed to the clinical and basic research of lung cancer, esophageal cancer and other solid tumors, and related research results have been published in top oncology journals such as Nature Cancer and NPJ Precision Oncology

Professor Hu Yi's team cooperated with the Air Force Military Medical University to report for the first time that the expression of ubiquitinspecific peptidase 10 (USP10) and histone deacetylase 7 (histone deacetylase 7, HDAC7) was highly correlated in esophageal cancer tissues, and its high expression was closely related to the poor prognosis of patients with esophageal cancer.

Professor Hu Yi's team is currently conducting a number of clinical studies related to histone deacetylase (HDAC) inhibitor drugs against tumors, and the basic research results will provide a theoretical basis and new strategies

Original Source:

Ma ZQ, Feng YT, Guo K, Liu D, Shao CJ, Pan MH, Zhang YM, Zhang YX, Lu D, Huang D, Zhang F, Wang JL, Yang B, Han J, Yan XL, Hu Y.