-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Image: Adam Higgins, Ohio State University College of Engineering
Source: Ohio State University College of Engineering
Research by the Oregon State University School of Engineering has found a promising potential treatment for neonatal jaundice, which is safer, simpler, and more convenient than the current blood transfusion for infants with the most dangerous jaundice
The study, led by Adam Higgins, associate professor of bioengineering, showed that microfluidics and high-intensity light can correct the dangerous accumulation of bilirubin in the blood
The results of the study were published in the journal Biological Microbiology
Neonatal jaundice is a common disease of newborns
The red color of blood comes from a protein called hemoglobin, which carries oxygen.
About two-thirds of newborns have varying degrees of jaundice, usually mild
Other cases with higher levels of bilirubin in the blood may require systemic phototherapy-the use of light to trigger a chemical reaction that causes the compound to be excreted more easily than bilirubin
Oregon State University’s research aims to provide a simpler and safer alternative: to circulate the patient’s blood through an external device called a microfluidic photoreactor
Microfluidics is the study of the behavior of fluids passing through or confined in micro devices equipped with channels and chambers
Higgins and his collaborators at the School of Engineering, Oregon Health and Science University, and the University of Washington used human blood and rat models in a laboratory environment to study the effect of LED lamps on pumping bilirubin-rich products through a microfluidic photoreactor.
Higgins said: "Research results show that high-intensity light with a wavelength of 470 nanometers can be used to quickly reduce bilirubin levels without causing any significant damage to the DNA of blood cells
Higgins said that the next step will involve scaling up the equipment used in Gunn rats to make it suitable for newborns about 10 times larger, and measuring blood DNA damage in preclinical animal models such as rhesus monkeys.
"But in general, it looks like the further development of photoreactor technology may lead to a promising new method to treat extremely high levels of bilirubin in the blood of newborns," he said
Article Title
Microfluidic photoreactor to treat neonatal jaundice
