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Recently, the research team of Sun Jiashu, a researcher at the National Nanoscience Center of the Chinese Academy of Sciences, cooperated with Jiang Zefei and Zhang Shaohua from the Fifth Medical Center of the Chinese People’s Liberation Army General Hospital, and Dai Bo, a professor at Fudan University’s Affiliated Tumor Hospital.
A series of progress has been made in the field of sense
.
Relevant research results were published in "Nature Communications" (Nature Communications, 2021, 12, 2536) and "Nano Today" (Nano Today, 2021, 38, 101203)
Metastatic breast cancer (MBC) is a heterogeneous disease that includes many different subtypes
.
Tumor-derived extracellular vesicles (EVs) in peripheral blood are important targets for liquid biopsy and have application prospects in accurate diagnosis and efficacy evaluation of MBC
Figure 1.
Application of EV surface protein detection based on thermophoretic aptamer sensor and accurate diagnosis of breast cancer
EV carries the mRNA of tumor cells and regulates tumor proliferation and metastasis at the transcriptional level.
It is an important cancer diagnostic marker
.
In order to overcome the challenges of complicated qRT-PCR detection operations and the need to lyse a large number of EVs, researchers have developed a new detection method (DTTA) that combines DNA tetrahedral probes and thermophoresis to achieve in situ and high sensitivity of EV mRNA in serum.
Figure 2.
The research work was funded by the National Natural Science Foundation of China, the National Science Fund for Distinguished Young Scholars, major research projects, and the Chinese Academy of Sciences Strategic Leading Science and Technology Project (Category B), the Key Frontier Science Research Project, and the Scientific Research Instrument and Equipment Development Project
