Microbiome: Eating less dietary fiber can cause cognitive dysfunction

Neurodegenerative diseases, including Alzheimer's disease (AD, the most common form of dementia), have devastating effects on affected individuals, their families, and health and social care systems
.

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Recently, the research team of Xuzhou Medical University published research results in Microbiome , and proposed for the first time the mechanism of cognitive dysfunction caused by lack of dietary fiber.
Supplementing the daily dietary fiber can delay the development of cognitive dysfunction to a certain extent
.

Recently, the research team of Xuzhou Medical University published research results in Microbiome , and proposed for the first time the mechanism of cognitive dysfunction caused by lack of dietary fiber.
Supplementing the daily dietary fiber can delay the development of cognitive dysfunction to a certain extent
.

Recently, the research team of Xuzhou Medical University published research results in Microbiome , and proposed for the first time the mechanism of cognitive dysfunction caused by lack of dietary fiber.

In this study, the researchers gave mice a dietary fiber-deficient diet (FD) for 15 weeks, and found that FD mice showed obvious cognitive impairment, manifested by the decline of object positioning memory, temporal memory and daily living ability
.

FD mice showed obvious cognitive impairment, manifested by the decline of object positioning memory, temporal memory and daily living ability
.

A lack of dietary fiber for 15 weeks can promote cognitive impairment and changes in synaptic ultrastructure
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15 mice were subjected to cognitive tests (AF) such as object location, time sequence memory, and nesting

A lack of dietary fiber for 15 weeks can promote cognitive impairment and changes in synaptic ultrastructure

The ultrastructure of hippocampal synapse in FD mice is obviously damaged, the synaptic gap is widened, the postsynaptic density is thinned, and the levels of presynaptic and postsynaptic markers are reduced

The lack of dietary fiber changes the hippocampal synaptic proteome for 15 weeks
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Quantitative analysis of the overall proteome of the AE hippocampus (n = 3), the CaMKIId in the hippocampus of FD mice is reduced as the core node of the cholinergic synapse and dopaminergic synaptic pathway

The lack of dietary fiber changes the hippocampal synaptic proteome for 15 weeks

The number, size and activity of microglia in FD mice increased, and the hippocampal inflammatory factors and microglia phagocytosis were obviously activated.

After 7 days of lack of dietary fiber, the intestinal flora changed and the mucus became thinner, but the cognitive ability did not decrease
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After 7 days of lack of dietary fiber, the intestinal flora changed and the mucus became thinner, but the cognitive ability did not decrease
.

Researchers analyzed the changes in gut microbes, colon parameters, and cognitive behaviors of short-term (7 days) FD mice, and found that short-term FD has been able to reduce the level of Bacteroides colon in mice, increase the level of Proteobacteria, and destroy Intestinal mucosa, but did not change the cognitive function of mice, indicating that FD- induced intestinal changes precede cognitive changes
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FD- induced intestinal changes precede cognitive changes
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FD- induced intestinal changes precede cognitive changes

The reduction of short-chain fatty acids due to fiber deficiency is essential for cognitive impairment
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SCFAs are important metabolites produced by the intestinal flora in the process of dietary fiber fermentation.
Supplementing SCFAs can improve the cognitive function of FD mice, reduce the loss of synaptic proteins, inhibit microglia activation and phagocytic synapses, and can partially Restore intestinal homeostasis in FD mice, and prevent intestinal-brain axis dysfunction caused by dietary fiber deficiency
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Supplementation of SCFAs can improve the cognitive function of FD mice, reduce the loss of synaptic proteins, inhibit microglia activation and phagocytic synapses, and partially restore the homeostasis of the intestinal tract of FD mice, and prevent the intestine caused by dietary fiber lack of diet- Brain axis dysfunction
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Supplementation of SCFAs can improve the cognitive function of FD mice, reduce the loss of synaptic proteins, inhibit microglia activation and phagocytic synapses, and partially restore the homeostasis of the intestinal tract of FD mice, and prevent the intestine caused by dietary fiber lack of diet- Brain axis dysfunction
.

The study found a powerful phenotype of cognitive decline in a mouse model of chronic dietary fiber deficiency, which is characterized by changes in the gut-hippocampal axis
.
It is worth noting that the imbalance of the intestinal microbiota and the reduction of SCFAs indicate that the lack of dietary fiber and the mutual influence between the host and the alteration of the intestinal-brain axis
.
The results of this study indicate that insufficient dietary fiber adversely affects brain function, and emphasizes nutritional strategies to increase fiber intake to reduce diet-related cognitive decline and the risk of neurodegenerative diseases
.

The study found a powerful phenotype of cognitive decline in a mouse model of chronic dietary fiber deficiency, which is characterized by changes in the gut-hippocampal axis
.
It is worth noting that the imbalance of the intestinal microbiota and the reduction of SCFAs indicate that the lack of dietary fiber and the mutual influence between the host and the alteration of the intestinal-brain axis
.
The results of this study indicate that insufficient dietary fiber adversely affects brain function, and emphasizes nutritional strategies to increase fiber intake to reduce diet-related cognitive decline and the risk of neurodegenerative diseases
.
The study found a powerful phenotype of cognitive decline in a mouse model of chronic dietary fiber deficiency, which is characterized by changes in the gut-hippocampal axis
.
It is worth noting that the imbalance of the intestinal microbiota and the reduction of SCFAs indicate that the lack of dietary fiber and the mutual influence between the host and the alteration of the intestinal-brain axis
.
The results of this study indicate that insufficient dietary fiber adversely affects brain function, and emphasizes nutritional strategies to increase fiber intake to reduce diet-related cognitive decline and the risk of neurodegenerative diseases
.

Original source

Shi, H.
, Ge, X.
, Ma, X.
  et al.
 A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites.
  Microbiome  9,  223 (2021).

Shi, H.
, Ge, X.
, Ma, X.
  et al.
 A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites.
  Microbiome  9,  223 (2021).
Shi, H .
, Ge, X.
, Ma, X.
  et al.
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