Metformin has a new role in repairing brain damage.

Medical Network July 31 - Metformin with a new role to come with a new role in the case of brain damage in the journal Nature Medicine, researchers from the University of Toronto Institute of Medical Sciences and Toronto Children's Hospital published the results of the trial: for children who have received craniofacial brain radiotherapy, compared to placebo, metformin significantly improved their work memory and statement memory function, repair white matter damage.
researchers concluded that clinical trials to examine the effects of metformin on cognitive and brain structure in long-term survivors of childhood brain tumors are feasible, and that metformin is safe to use and tolerate in this population.
the trial was not specifically tested for cognitive recovery and brain growth, but the preliminary results were encouraging and merited further study in the large multicenter phase 3 trial.
, using different tests to analyze the recovery of three types of cognitive function sourcing impaired working memory, statement memory, and information processing speed, using different tests.
results showed that metformin performed significantly better than placebo, especially working and stated memory, and that patients who used metformin before placebo had better cognitive function than those who used metformin before placebo.
in addition, they studied whether pharmacological stimulation of endogenous neuroprecursor cells (NPC) in parallel rodent and human radiation injury studies can promote cognitive recovery and brain repair, with a focus on the drug metformin.
in the rodent's cranial radiation model, they found that metformin enhanced the recovery of toothed back to THE CEC and was gender-dependent on neurogenesis and cognition.
finally, the researchers believe that metformin is tolerable and safe for post-treatment childhood brain tumor patients, and that there is a preliminary indication of cognitive recovery, which is consistent with the previously found low incidence of dementia in alzheimer's disease in patients with type 2 diabetes who took metformin, and greater audio-visual memory.
2, the performance of the record: 25 newly discovered minine net data show that metformin as the core of the global diabetes drug, in 2018 in China's public medical institutions, physical pharmacies and other sales terminals total market size of more than 6 billion yuan, as a non-patented drug, Cypress Blue in the official website of the State Drug Administration to "metformin" as the keyword search, a total of 306 approvals, involving a large number of enterprises.
With the further research, the treatment potential of the drug metformin is constantly expanding, the treatment of brain damage, promote cognitive recovery role is the first time, in the future, we look forward to these studies in the clinical further expansion.
1, weight loss effect metformin is a sugar-lowering drug that can lose weight.
it increases insulin sensitivity and reduces fat synthesis.
For many type 2 sugar friends, weight loss is in itself a good thing for blood sugar stability control.
a study by the U.S. Diabetes Prevention Program (DPP) research team, patients treated with metformin lost an average of 3.1 kilograms over a non-blind study of seven to eight years.
2, anti-aging effect, the United States Food and Drug Administration is approved "with metformin anti-aging" clinical trials, foreign scientists are the reason for metformin as an anti-aging candidate, probably because metformin can increase the number of oxygen molecules released into cells, from the point of view, this seems to increase the body's robustness and extend life.
3, the international scientific journal Nature, which reverses biological age, published a blockbuster news story. A small clinical study in California has shown for the first time that reversing the epigenetic clock is possible, according to
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over the past year, nine healthy volunteers took a mixture of growth hormone and two diabetes drugs, including metformin.
measured by analyzing markers on a person's genome, their biological age declined by an average of 2.5 years.
4, the results of the study, northwestern University Professor Scott Budinger team in mice confirmed that metformin can prevent haze-induced inflammation, prevent immune cells release a dangerous molecule into the blood, inhibit the formation of arterial thrombosis, thereby reducing the risk of cardiovascular disease.
, researchers at the University of Pennsylvania, which helped quit smoking, found that long-term nicotine use led to the activation of the AMPK signaling pathway, which is inhibited when nicotine quits.
they reasoned that activating the AMPK signaling pathway with drugs could relieve withdrawal.
metformin is an AMPK agonis.
when researchers used metformin in mice that produced nicotine withdrawal reactions, they found that this could relieve the withdrawal response in mice.
their research showed that metformin could be used to help quit smoking.
6. Preclinical and clinical studies of anti-inflammatory behavior show that metformin can not only improve chronic inflammation by improving the metabolic parameters of blood lipid abnormalities such as high blood sugar, insulin resistance and atherosclerosis, but also have a direct anti-inflammatory effect.
studies have shown that metformin inhibits inflammatory responses, mainly through AMP activated protein kinase (AMPK) - dependent or non-dependent methods to inhibit nuclear transcription factor B (NFB).
7. The team of Chinese scientist Shuang Jing, who treats hair loss, found that drugs such as metformin and rapamycin can stimulate the life of the hair follicles in mice, promoting hair growth, and the relevant research was published in the prestigious academic journal Cell Reports.
, when they treated patients with polycystic ovary syndrome in China and India with metformin, they also observed that metformin was associated with reduced hair loss.
, different studies have shown new discoveries about diseases that affect women's health.
8. A study in the Journal of The Lancet, which reduces the risk of miscarriage and premature birth in a particular pregnant woman, showed that metformin may reduce the risk of miscarriage and premature birth in a particular pregnant woman.
scientists from the Norwegian University of Science and Technology (NTNU) and St. Olavs Hospital conducted a nearly 20-year study that found that patients with polycystic ovary syndrome who take metformin at the end of three months of pregnancy may reduce the risk of late miscarriage and premature birth.
9, improve polycystic ovary syndrome polycystic ovary syndrome is a heterogeneous disease characterized by ostotrophicemia, ovary dysfunction, polycystic ovary morphology, the pathogenesis is unclear, patients often have different degrees of hyperinsulinemia.
studies have shown that metformin can improve ovulation by reducing insulin resistance, restoring its ovulation function and improving koostogenicemia.
10, a combination of drugs, or Dr. Marsha Rich Rosner of the University of Chicago, which treats sanybreast cancer, found that metformin, in combination with another old drug, panhematin, could target the treatment of triyukuinal breast cancer, which is a serious threat to women's health.
and there is evidence that this treatment may be effective for a variety of cancers, including lung cancer, kidney cancer, uterine cancer, prostate cancer and acute myeloid leukemia, the study was published in the leading journal Nature.
11, cardiovascular protection effect metformin has cardiovascular protection effect, is currently the only diabetes guidelines recommended as a clear evidence of cardiovascular benefits of the sugar-lowering drugs.
studies have shown that the long-term treatment of metformin is significantly associated with a significant reduction in the risk of cardiovascular disease in newly diagnosed type 2 diabetes patients and in patients with type 2 diabetes who have developed cardiovascular disease.
12, improve the intestinal flora has been shown that metformin can restore the proportion of intestinal flora, so that it is beneficial to the direction of health.
provides an advantage for gut beneficial bacteria, which can lower blood sugar and regulate the immune system positively.
13, is expected to treat some of the autism, and researchers at McGill University have found that metformin can treat some forms of autism with brittle X syndrome, and the innovative study was published in the journal NatureMedicine.
autism is one of many medical conditions that scientists believe can be treated with metformin.
14, researchers at the University of Alabama at Birmingham found that in human iexclusiveciatic pulmonary fibrosis patients and mice with bolemycin-induced lung fibrosis models, ampK activity in fibrosis tissue decreased, and tissue resistance to apoptosis of myocellular fibrosis increased.
activating AMPK with metformin in myofibre cells can make these cells resensitive to apoptosis.
and metformin in mouse models can accelerate the ablation of the fibrosis tissue that has been produced.
this study showed that metformin or other AMPK agonists could be used to reverse the fibrosis that has been produced.
15, researchers at the University of Texas at Dallas, texas, built a mouse model that simulates pain-related cognitive impairment.
they used the model to test the efficacy of multiple drugs.
results showthat the treatment of mice with 200 mg/kg of metformin at 200 mg/kg of weight can completely reverse cognitive impairment due to pain.
and the gabarpentine, which treats nerve pain and epilepsy, has no such effect.
this means that metformin can be used in old medicinetominos to treat cognitive impairment in patients with nerve pain.
16, inhibit tumor growth, according to the news, the European Institute of Oncology scholars found that metformin and fasting can be a synergy to inhibit the growth of tumors in mice.
further studies have found that metformin and fasting inhibit tumor growth through the PP2A-GSK3 beta-MCL-1 pathway, published in Cancer Cell.
17, Dr. Yu-Yen Chen of Taichung Rongmin General Hospital in Taiwan, China, found that the age-related macular degeneration (AMD) incidence of type 2 diabetes with metformin was significantly lower.
this shows that the anti-inflammatory and antioxidant function sofido metformin has a protective effect on AMD while controlling diabetes.
18, or reduce adverse reactions to glucocorticoids, The Lancet-Diabetes and Endocrinology recently published a study showing that in Phase 2 clinical trials, metformin used in patients with chronic inflammatory diseases can improve metabolic health and reduce the serious side effects of glucocorticoid therapy.
there are experimental indications that metformin may work through the key metabolic protein AMPK and, contrary to the mechanism of the action of glucocorticoids, has the potential to reverse the side effects of heavy use of glucocorticoids.
19, is expected to treat multiple sclerosis, the University of Cambridge's Robin J.M. Franklin and his brother Peter van Wijngaarden, writing in the top journal Cell Stem Cells, found a special class of aging neural stem cells that, after metformin treatment, can restore response to differentiation-promoting signals, re-create youthful vitality and further promote the regeneration of neuromyeloids.
this finding means that metformin is expected to be used to treat irreversible neurodegenerative-related diseases, such as multiple sclerosis.
20, is expected to improve the risk of kidney failure and kidney disease death, the Mingkangd content team medical new point of view, said that 10,000 studies show that metformin may improve the risk of kidney failure and kidney disease death.
a study published in Diabetes Care, a journal of the American Diabetes Association (ADA), showed that drug use and survival analysis of more than 10,000 people showed that patients with type 2 diabetes who combined chronic kidney disease (CKD) were associated with a reduced risk of death and end-stage kidney disease (ESRD) without increasing the risk of lactic acidosis.
although metformin has so many exciting findings, but the drug tritoxic, we do not buy their own medicine to take, to use under the guidance of a physician.
21, can protect the stomach, reduce the risk of stomach cancer recently, the world's top scientific journal "CELL" sub-journal "Cell Stem Cell" updated the latest research on metformin: metformin can regulate the metabolism of stem cells in the stomach, prompting them to differentiate into stomach acid-producing stomach wall cells.
studies have shown that ampK metabolic pathways promote stem cell production of wall cells that secrete acids, and that metformin slows the proliferation of progenitor cells by activating AMPK and KLF4, but also induces wall cell maturation by activating AMPK and PGC1a, which provides a potential hint of why metformin increases acid secretion and reduces the risk of stomach cancer in humans.
in addition, a 2018 study showed that the use of metformin reduced the risk of stomach cancer by 51 percent in diabetics who eradicated Helicobacter pylori in a sustained and dose-based manner.
22, preoperative to reduce the mortality rate of patients according to the drug Mingkang's account medical new point of view news, a recent study published in the Journal of the American Medical Association - Surgery found that the classic sugar-lowering drug metformin in addition to the control of blood sugar another benefit: preoperative use of metformin may be associated with postoperative mortality and reduced risk of readmission in diabetic patients.
23, extend the survival time of patients with advanced bowel cancer carrying KRAS mutation according to Singpoint.com, recently, the Chinese team of scientists at Zhongshan University Zhongshan Medical School Gao Guoquan team published important research results in the well-known journal PNAS.
they analyzed treatment data from thousands of patients with advanced bowel cancer who carried kraS mutations and found that in patients with advanced bowel cancer who carried the KRAS mutation, the total survival time of bowel cancer patients who took metformin was 37.8 months longer and the median progression-free survival time (mPFS) was 8.1 months longer than those who took other types of anti-sugar drugs.
24, Cancer and Stroke Prevention Trends According to New Viewpoint, the American Diabetes Association's 80th Scientific Meeting (2020ADA Annual Meeting) released the latest data from the Diabetes Prevention Program Results Study (DPPOS) - metformin continues to reduce the risk of diabetes for 22 years, showing the risk of preventing cancer and stroke.
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