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Merck's first in class cytomegalovirus infection new drug "Letermovir" approved in China

 Last Update: 2022-01-26
 Source: Internet
 Author: User

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On January 5, Merck's Litemovir tablets were approved by the State Food and Drug Administration for marketing
.

Cytomegalovirus (CMV) seropositive adult recipients [R+] for allogeneic hematopoietic stem cell transplantation (HSCT) to prevent CMV reactivation and disease

CMV is a common herpes virus with a positive rate of 30% to 97% in human serum
.

Immunocompetent people usually present with short-term fever or asymptomatic infection after CMV infection

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) has been successfully used in the treatment of hematological diseases, but infection after transplantation is still an important factor affecting survival.
Among them, CMV infection is the most common viral infection after transplantation, which mostly occurs 100 days after transplantation.
If not treated in time, it can cause multiple organ damage and even life-threatening
.

Letermovir inhibits the CMV viral DNA terminase complex (pUL51, pUL56, pUL89)
.

This enzyme is used for the processing and packaging of viral DNA

Letermovir was first approved by the FDA in November 2017 for the prevention of CMV infection in adult recipients of CMV IgG-positive Allo-HSCT
.

The National Comprehensive Cancer Network (NCCN) Practice Guidelines for the Prevention and Treatment of Tumor-Associated Infections (2020) recommend Letermovir as the first-line prophylaxis in CMV IgG-positive Allo-HSCT recipients, that is, CMV prophylaxis prior to preemptive treatment measures

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