MER verifies the accuracy of the 7T-ML method for locating STN

ref:Shamir RR,et al..
2018 May 24doi: 10.1093/neuros/nyy212(Epub ahead of print)deep brain stimulation (SB)the hypothalamic nucleus, STN) is an effective way to treat the movement disorder of Parkinson's disease (Parkinson's disease, PD); Ultra-high field 7T MRI human brain anatomical images can show clear STN subdivision nuclear groupsComparing the 1.5T, 3T and 7T MRI-T2 weighted imaging positioning STN and microelectrode recording (microelectrode recordings, MER) positioning STN found that the STN boundary of 1.5T and 3T MRI positioning was significantly inward-oriented to mer, averaging about 2mm;only a few research institutions are currently able to try 7T MRI devices, which have not yet been clinically appliedTherefore, Reuben RShamir of the Institute of Surgical Information Science in Minneapolis, Minnesota, USA, integrated the 7T MRI imaging and machine learning (machine-learning, ML) method (7T-ML method) for PD patients, established a 7T MRI data information model to compare the position and shape of STN on clinical 3T MRI images, and then verified the accuracy of the 7T-ML method by micro-electrode recording stN positioning results published in May 201816 Patients with PD underwent MER-positioned STN-DBS surgery, with a total of 30 electrodes implanted, of which 14 were two-sided implants and 2 single-sided implants Based on the clinical 3T MRI imaging data, the STN positioning results calculated by 7T-ML method and the STN positioning of MER detection were compared to the correlation between the length and contact position of the electrode trajectory and the STN back, inner or abdominal side The double-blind study's MER and MRI scans were performed in Jerusalem, while calculations based on MRI imaging data were performed in Minnesota results show that 30 electrodes using the 7T-ML method and MER-positioned electrode trajectory are intersecting with STN The average length of the STN track detected by MER is 6.2 to 0.7mm, while the average length of the STN track calculated by the 7T-ML method is 5.8 to 0.9mm 93% of the MER detection and 7T-ML method positioning of the contact position is the same (Figure 1) Figure 1 1 typical case The 7T-ML method calculates that the STN position is exactly matched to the MER detection information: contacts 0 and 1 are inside the STN, contact 2 intersects its part, and contact 3 is on the outside back side of the STN the authors point out that the results of the 7T-ML method are highly consistent with the microelectrode recording detection data This method can accurately implant and locate DBS electrodes to improve the efficacy of DBS (Hu Kejia, of Ruijin Hospital, affiliated with Shanghai Jiaotong University Medical School, compiled , Professor Wang Zhiqiu , of Huashan Hospital, Fudan University, revised, editor-in-chief of "Outside Information" and professor chen Zhicheng , a of Fudan University)