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Various epidemiological studies have shown a link between miscarriage and the risk of breast cancer in women without a spouse, but the results remain conclusive.
the relevance of this meta-analysis is evaluated on the basis of previous research.
searched the PubMed, EMBase, China National Knowledge Infrastructure, Chongqing VIP and Wanfang databases by February 2018.
in this meta-analysis, a fixed effect model is used to estimate the size of the combined effect and the corresponding 95% confidence interval (CI).
all statistics are analyzed using STATA 12.0.
review included 14 articles, including 6 cohort studies and 8 case-control studies.
based on the Newcastle Ottawa Scale assessment, all articles are of high quality.
comprehensive risk ratio (RR) shows that there is no significant association between abortion and breast cancer in women who are infertile (RR-1.023, 95% CI-0.938-1.117; Z-0.51, P-607).
subgroup analysis showed that there was no significant association between breast cancer risk and abortion or between breast cancer risk and spontaneous abortion (SA) in women who did not have children (RR s 1.008, 95% CI - 0.909-1.118 and RR s 1.062, 95% CI - 0.902-1.250) respectively.
1 or 2 abortions did not increase the risk of breast cancer in women who did not have children.
sensitivity analysis shows that the results of this study are reliable and stable.
in general, evidence based on epidemiological studies suggests no association between miscarriage and breast cancer risk in infertile women.
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