Medicinal grade xanthan gum use properties

Medicinal grade xanthan gum for use Xanthan gum is a light yellow to white flowable powder with a slight odor
.

Easily soluble in cold and hot water, neutral solution, resistant to freezing and thawing, insoluble in ethanol
.

Water dispersion, emulsification into a stable hydrophilic viscous colloidal xanthan gum due to its nature, so in food, petroleum, medicine, daily chemical and other more than a dozen fields have an extremely wide range of applications, its degree of commercialization is high, the scope of application is wide, so that any other microbial polysaccharides 1, food: many foods are added xanthan gum as stabilizers, emulsifiers, suspension agents, thickeners and processing aids
.

Xanthan gum can control the rheology, structure, flavor and appearance of the product, and its pseudo-plasticity can ensure a good taste, so it is widely used in salad dressings, bread, dairy products, frozen foods, beverages, condiments, brewing, candy, pastries, soups and canned foods
.

In recent years, people in more developed countries are often worried that the calorific value in food is too high to make them fat, and xanthan gum has dispelled this concern
because it cannot be directly degraded by the human body.

In addition, according to a 1985 report in Japan, xanthan gum was an effective anti-cancer agent for comparative testing of eleven food additives
.

2, daily chemical: xanthan gum molecules contain a large number of hydrophilic groups, is a good surfactant substance, and has antioxidant, prevent skin aging and other effects, therefore, almost the vast majority of high-end cosmetics will be xanthan gum as its main functional component
.

In addition, xanthan gum can also be used as a component of toothpaste to thicken the texture and reduce tooth surface wear
.

【Inspection】Viscosity Take 250ml of water, put it in a beaker, adjust the speed of the low-pitch agitator or magnetic stirrer to 800 rpm, slowly add 3.
0g (according to the dried product) and 3.
0g of the mixture of this product while stirring, continue to stir for 10 minutes, rinse the beaker cup wall with 44ml of water while stirring, stop stirring, quickly shake the beaker, make the particles on the beaker completely immersed in the solution, adjust the temperature to 25 °C±1 °C, Continue to stir at 800 rpm for 2 hours (during the stirring process, the beaker can be properly rotated to avoid sample stratification, and the time of each shake is controlled within 30 seconds, if the sample is difficult to mix evenly, the stirring time can be appropriately extended) as the test solution
.

Take an appropriate amount of the test solution, place the coaxial cylinder rotation viscometer with a diameter of 25mm in the inner cylinder and a diameter of 27mm in the outer cylinder, the depth of immersion of the inner cylinder into the sample is 42mm, at a speed of 18 revolutions per minute or an angular velocity of 1.
885rad・s-1 (or select suitable measurement conditions, so that the shear rate is 24s-1), measured according to law [General 0633 Third Method (1)], the dynamic viscosity at 25 ° C should not be less than 0.
6Pa・s
。
Pyruvic acid Take 60.
0mg of this product, put it in a 50ml grinding flask, add 10.
0ml of water to dissolve, add lmol/L hydrochloric acid solution 20.
0ml, weigh the weight of the flask, heat reflux for 3 hours, let it cool, weigh the flask, replenish the evaporated water; take the precision amount of 2ml, put it in a separating funnel, add 2,4-.
0g, add 2mol/L hydrochloric acid solution 200ml to dissolve, shake well, add ethyl acetate 5ml, shake, shake, Let stand to make the layering, discard the aqueous layer, extract 3 times with sodium carbonate test solution, 5 ml each time, combine the extraction solution, place it in a 50 ml measuring bottle, dilute with sodium carbonate test solution to the scale, shake well, as a test solution; Take another 45.
0mg of pyruvate, place it in a 500ml measuring bottle, dissolve it with water and dilute it to the scale, shake well, take a precise amount of 10ml, place it in a 50ml grinding flask, according to the preparation method of the test solution, from "add lmol/L hydrochloric acid solution 20.
0ml", operate according to law, as a control solution
.

According to the ultraviolet-visible spectrophotometry (General Principle 0401), the absorbance
was determined at a wavelength of 375 nm with sodium carbonate as a blank.

The absorbance of the sample solution shall not be less than the absorbance of the control solution (1.
5%)
.

Nitrogen content Take about 0.
1g of this product, precisely weighed, measured according to the nitrogen determination method (general 0704 second or third method), calculated according to the dried product, the nitrogen content shall not exceed 1.
5%.
Residual solvent methanol, Ethanol and isopropanol take about 2.
5g of this product, precision weighing, placed in a 500ml stoppered Erlenmeyer flask, add 1ml of dimethicone oil and 100ml of water, shake while adding water, shake for 1 hour, set the electric heat cover to heat distillation, with 10ml of water as the absorption solution, when the distillate is nearly 45ml, so that the lower end of the condensate tube leaves the collection liquid level, and then distilled for 1 minute, and with a small amount of water to wash the device part of the collection solution, precision add the internal standard solution (0.
1% tert-butanol solution) 2ml, And dilute with water to 50ml, shake well, precise amount of 5ml placed in the top empty bottle, sealed, as a test solution; Respectively, precise weigh methanol, ethanol and isopropanol appropriate amount, dilute with water into a mixed solution containing about 3.
6mg, 6mg and 1mg per 1ml, precise amount of 2ml and internal standard solution 2ml, placed in a 50ml measuring bottle, diluted with water to the scale, shake well, precision amount of 5ml placed in the top empty bottle, sealed, as a control solution
.

According to the residual solvent determination method (General Principle 0861 first method), the capillary column with 6% cyanopropylphenyl-94% dimethicone (or polar similar) as the fixative solution is the column; The column temperature is 40C, the inlet temperature is 200°C, and the detector temperature is 280°C; The equilibrium temperature of the headspace bottle is 70 °C, the equilibration time is 10 minutes, and the headspace injection of the control solution should be taken, and the separation between each peak should meet the requirements
.

Take the test solution and the control solution to inject the headspace, record the chromatogram, calculate the peak area according to the internal standard method, and the methanol and ethanol should meet the regulations, and the isopropanol content shall not exceed 0.
075%.
Drying weight loss Take this product, dry at 105 ° C to constant weight, the weight loss shall not exceed 15.
0% (General 0831).
Ash Take 1.
0g of this product, place it in a crucible of constant weight, slowly burn until it is completely carbonized, gradually increase the temperature to 500 ~ 600 ° C, so that it is completely ashed and constant weight, according to the calculation of dry products, the residual residue shall not exceed 16.
0%.
Heavy metals Take the residue left under the ash sub-item, check according to law (General Principle 0821 Second Law, filtered if necessary), and contain heavy metals shall not exceed 20 parts
per million.

Arsenic salt Take this product 0.
67g, add calcium hydroxide 1.
0g, mix, add water to an appropriate amount, stir evenly, after drying, burn with a small fire to make carbonization, and then 500 ~ 600 ° C to make complete ash, let cool, add 8ml of hydrochloric acid and 23ml of water, check according to law (general 0822 first law), should meet the regulations (0.
0003%)
.

Microbial limits take this product, check according to law (General Principle 1105 and General Principle 1106), the total number of aerobic bacteria in each 1g of the test product shall not exceed 103cfu, the total number of mold and yeast shall not exceed 102cfu, and Escherichia
coli shall not be detected.

3.
Medical aspects: xanthan gum is a functional component in the internationally hot microencapsulated drug capsule, and plays an important role in controlling the sustained release of drugs; Due to its own strong hydrophilicity and water retention, there are many applications for specific medical operations, such as the formation of a tight water film, thus avoiding skin infections; Relieve the patient's thirst after radiation therapy, etc
.

In addition, Li Xin and Xu Lei have written that xanthan gum itself has a significant enhancing effect
on the humoral immune function of mice.

4, industrial and agricultural applications: in the petroleum industry, due to its strong pseudoplasticity, low concentration of xanthan gum (0.
5%) aqueous solution can maintain the viscosity of the drilling fluid and control its rheological properties, so the viscosity at the high-speed rotating drill bit site is extremely small, saving power; The relatively stationary drilling area maintains a high viscosity, thus preventing the well wall from collapsing
.

And because of its excellent salt resistance and heat resistance, it is widely used in drilling in special environments such as marine and high saline layer areas, and can be used as oil recovery flooding agent to reduce dead oil areas and improve oil recovery rate
.