Medicinal grade sodium cirphyrate Shanxi Jinyang

Medicinal Grade Sodium Cyrulate Uses Sodium Cyrulate As a strong sweetener, it can be applied to pharmaceutical preparations, food, beverages and catering
.

Its dilute solution of about 0.
17% w/v is about 30 times sweeter
than sucrose.

However, with increasing concentration, its sweetness decreases, and when a concentration of 0.
5% w/ v is reached, there is a pronounced bitter taste
.

Sodium cyclolate enhances the taste system and can be used to mask certain undesirable tastes
.

In most cases, sodium cyclic acid is used
in combination with saccharin.

Sodium cyclolarate, a white crystalline powder; Odorless and sweet
.

It is easily soluble in water, very slightly soluble in ethanol, and insoluble
in B and III.

Can be used for medicinal excipients and flavoring agents, etc.
[check] absorbance Take this product 1.
0g, add 10ml of water to dissolve, according to the ultraviolet - visible spectrophotometry (general rule 0401), at a wavelength of 270 nm to determine the absorbance, not more than 0.
10
.

PH Take 1.
0g of this product, add 10ml of water to dissolve, determine according to law (general 0631), pH value should be 5.
5 ~ 7.
5
.

The clarity and color of the solution Take the solution under the pH, check according to law (General Principle 0901 and General Principle 0902), and should be clear and colorless
.

Sulfate Take 0.
50g of this product, check according to law (general 0802), and compare with the control solution made of standard potassium sulfate solution of 1.
2ml, no more concentrated (0.
024%)
.

Cyclohexylamine Take 10g of this product, weigh it precisely, place it in a 100ml measuring bottle, add water to dissolve and dilute to the scale, shake well, as a test solution; Also take cyclohexylamine control 0.
1g, precision weighing, placed in a 100ml measuring bottle, quickly add hydrochloric acid solution (1→100) 50ml to dissolve, and dilute with water to the scale, shake well, precise amount to take the appropriate amount, quantitative dilution with water to make a solution containing cyclohexylamine 2.
5 μg per 1ml, as a control solution
.

Precise amount of test solution and control solution 10ml each, respectively placed in a 60ml separating funnel, add alkaline disodium edetate solution (take eddigamidate disodium 10g and sodium hydroxide 3.
4g, add water to dissolve and dilute to 100ml, shake well, that is) 3.
0ml and - butanol (20).
: 1) 15.
0ml, shake for 2 minutes, stand, take three layers, take 10ml of precision amount, put in another liquid funnel, add methyl orange boric acid solution (take methyl orange 200mg and boric acid 3.
5g, add 100ml of water, heat it on a water bath to dissolve, let it stand for more than 24 hours, filter before use, take the filtrate, that is) 2.
0ml, shake for 2 minutes, let stand, take three layers, add anhydrous sodium sulfate 1g, shake, stand; precision measure take 5ml of three layers of solution, place in a colorimetric tube, add methanol-sulfuric acid (50).
: 1) 0.
5ml, shake well, the color of the sample solution shall not be deeper than the control solution; or according to the ultraviolet-visible spectrophotometry (general 0401), the absorbance is determined at a wavelength of 520 nm, and the absorbance of the sample solution shall not be greater than the absorbance of the control solution (0.
0025%)
.

Drying weight loss Take this product, dry at 105 ° C to constant weight, the weight loss shall not exceed 1.
0% (General 0831).
Heavy metals Take 1.
0g of this product, add 23ml of water to dissolve, add acetate buffer (pH 3.
5) 2ml, check according to law (general 0821 first law), containing heavy metals shall not exceed 10 parts
per million.

Arsenic salt Take 2.
0g of this product, add 22ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General Principle 0822 First Law), should comply with the regulations (0.
0001%)
.