Medicinal grade dibutyl hydroxytoluene Property

The chemical properties of pharmaceutical grade dibutylhydroxytoluene 2,6-di-tert-butyl p-cresol has nearly 70 years of application history, is a large-yield phenol antioxidant (rubber industry called antioxidant).

2,6-Di-tert-butyl-p-cresol was recognized by the FDA before 1958 as a food additive to delay food rancidity
.

Used in organic synthesis, used as rubber, plastic antioxidant, gasoline, transformer oil, turbine oil, animal and vegetable oil, food and other antioxidants
.

Colorless crystalline or white crystalline powder, odorless, odorless
.

Easily soluble in ethanol (25%, 25 °C), acetone (40%), benzene (40%), soybean oil, cottonseed oil, insoluble in water, glycerin, propylene glycol
.

It is stable to light and heat, and the heating can be volatilized together with water vapor, and the metal ions do not change color
.

【Content Determination】 Measured by high performance liquid chromatography (General 0512
).

Chromatographic conditions and system suitability test with octadecyl silane bonded silica gel as a filler; Methanol-water (9:1) is used as the mobile phase, and the detection wavelength is 278 nm
.

The theoretical plate number is calculated according to the dibutyl hydroxytoluene peak not less than 3000
.

Assay Method Take about 20mg of this product, precise weighing, placed in a 100ml measuring flask, add an appropriate amount of methanol to dissolve and dilute to the scale, shake well, as a test solution, precise amount of 10 μl injected into the liquid chromatograph, record the chromatogram; A dibutylhydroxytoluene control was also taken and determined
by the same method.

Calculated according to the external standard method in terms of peak area, it is obtained
.