Medicinal grade chlorocresol cas59-50-7 uses

Medicinal grade chlorocresolcas59-50-7 use Chlorocresol is used as a bacteriostatic agent in cosmetics and prescription preparations
.

In addition to oral preparations, its concentration in various formulations can reach 0.
2%.

Chlorocresol is effective against bacteria, spores, molds and yeasts; It has the greatest
activity in acidic media.

In the presence of certain excipients, especially nonionic surfactants, its bacteriostatic effect will be reduced
.

At higher concentrations, chlorocresol is an effective disinfectant [check] acidity Take 3.
0g of this product, fine, add 60ml of water, shake for 2 minutes, filter, take 10ml of filtrate, add methyl red indicator liquid 0.
1ml, the solution appears orange or red
.

Add 0.
01mol/L sodium hydroxide solution, that is, it appears yellow, and the amount of sodium hydroxide solution added shall not exceed 0.
2ml
.

The clarity and color of the solution Take 1.
25g of this product, add ethanol 25ml to dissolve, check according to law (General 0901 and General 0902), the solution should be clear and colorless; If the color is developed, it shall not be deeper
than that of the orange-red No.
2 standard colorimetric solution (general rule 0901 first method).

About the substance Take 1.
0g of this product, precision weighing, placed in a 100ml measuring bottle, add acetone dissolved and diluted to the scale, shake well, as a test solution; precision dose take 1ml, placed in a 100ml measuring bottle, dilute with acetone to the scale, shake well, take 10ml with precision, put in a 100ml measuring bottle, dilute with acetone to the scale, shake well, as a control solution; take another m-cresol control product appropriate amount, precision weighing, add acetone dissolution and quantitative dilution into a solution containing 50 μg per 1ml, as a
。
According to gas chromatography (General Rule 0521), the capillary column with 35% phenyl-65% methyl polysiloxane (or similar polarity) as the fixative liquid is a column (30m×0.
32mm, 0.
50μm, DB-17 column is suitable or equivalent to the performance of the column), the column temperature is 125 °C; Inlet temperature is 210°C; The detector temperature is 280°C
.

Take an appropriate amount of o-cresol and m-cresol control, add acetone to dissolve and dilute to make a mixed solution containing 50 μg per 1ml, take 1 μl into the gas chromatograph, and the separation of o-cresol peak and m-cresol peak should meet the requirements
.

Precision dose of control solution into the gas chromatograph, chlorocresol peak retention time of about 8 minutes, precision dose of the control solution, control solution and test solution 1 μl each, respectively injected into the gas chromatograph, record the chromatography to the main peak retention time of 3 times
.

If there is an impurity peak in the test solution, m-cresol shall not exceed 0.
5% according to the external standard method in terms of peak area, the peak area of other single impurities shall not be greater than the main peak area of the control solution (0.
1%), and the sum of the peak area of other impurities shall not be greater than 5 times (0.
5%)
of the main peak area of the control solution.

No volatiles Take 2.
0g of this product, place in an evaporation dish dried to constant weight at 105 ° C, heat and drain on a water bath, dry to constant weight at 105 ° C, and the residual residue shall not exceed 2mg (0.
1%)
.