Medicinal grade chitosan cas9012-76-4 use

Medicinal grade chitosan cas9012-76-4 The properties of this product are related to its properties of polyelectrolytes and glycans
.

The presence of large amounts of amino acids allows chitosan to undergo a chemical reaction with the anionic system, so the combination of these two substances will cause changes
in physicochemical properties.

When chitosan is stored and used as a solution, it needs to be in an acidic environment, but due to the presence of acetal structure, it degrades in the acidic solution, and the viscosity of the solution decreases
accordingly.

If ethanol, methanol, acetone, etc.
can delay the viscosity of chitosan solution, with ethanol acting on white or light yellow flake powder, easily soluble in the aqueous solution of organic acids, the formation of cationic chitosan, can be combined with the amino acids of keratonin to form a chemical bond binding, with good straight hair fixation effect
.

【Inspection】 Deacetylity Take about 0.
5g of this product, weigh it precisely, add 18ml of hydrochloric acid titration solution (0.
3mol/L) with precision, stir at room temperature for 2 hours to dissolve, add 1% methyl orange indicator 3 drops, titrate with sodium hydroxide titration solution (0.
15mol/L) to become orange
.

Calculated as follows, the degree of deacetyl should be greater than 70%.
NHCL is the concentration of hydrochloric acid titration solution (0.
3 mol/L), mol/L; VHCL is the volume of hydrochloric acid titration solution (0.
3mol/L), ml; NNaOH is the concentration of sodium hydroxide titration solution (0.
15 mol/L), mol/L; VNaOH is the volume of sodium hydroxide titration solution (0.
15 mol/L), ml; G is the sampling amount of the sample for the test, g; W is the drying weightlessness of the test product, %; 0.
016 is the amount of amino equivalent to 1mol / L hydrochloric acid, g; 9.
94% is the theoretical amino content
.

PH Take 0.
50g of this product, add 50ml of water, stir for 30 minutes, let stand for 30 minutes, determine according to law (general 0631), pH value should be 6.
5 ~ 8.
5
.

Protein Take 0.
1g of this product, put it in a 10ml measuring bottle, add 1% glacial acetic acid solution to dissolve and dilute to the scale, shake well, take the appropriate amount with precision, and measure according to law (General 0731 Fifth Method), protein shall not exceed 0.
2%.
Loss on drying Take 1.
0g of this product, dry at 105 ° C to constant weight, and the weight loss shall not exceed 10% (General 0831).
Blazing residue Take 1.
0g of this product, check according to law (General Principle 0841), and the residual residue shall not exceed 1.
0%.
Heavy metals Take the residue under the burning residue and inspect it according to law (General Principle 0821 Second Law), and the heavy metal shall not exceed 10 parts
per million.

Arsenic salt Take 2.
0g of this product, add 1.
0g of calcium hydroxide, mix, add 2ml of water, stir evenly, steam dry on the water bath, burn it with a low fire to make carbonization, and then burn it to make it completely ashed at 500 ~ 600 ° C, let it cool, add 5ml of hydrochloric acid, add 23ml of water, check according to law (general principle 0822 first law), should meet the regulations (0.
0001%)
.

【Category】Pharmaceutical excipients, disintegants, thickeners, etc
.