Medical enzyme: a new favorite of green industry

The global climate change and environmental pollution have caused serious harm to human life, which makes the society pay more attention to the construction of green industrial system In the next 10 years, China will use industrial biotechnology to promote green manufacturing industry and develop green GDP Among them, enzyme technology, as the key technology to realize green industry, has a very wide range of applications in food, textile, pharmaceutical and other industries, especially in the "green pharmaceutical" industry, it has played an irreplaceable important role China's enzyme industry has gained a certain international voice in production and export, however, it is still weak in higher-end medical use The export volume of China's enzyme industry has increased rapidly, and now it has formed an annual production scale of nearly 400000 tons, with a total sales volume of about 500 million yuan It has entered the ranks of the world's largest enzyme production countries, and at least 28 kinds of enzymes have been produced on a large scale With the continuous increase of enzyme production in China, many industrial enzymes have been exported in large quantities, among which the three largest export enzymes are (Aspergillus niger) glucoamylase, α - amylase and β - glucanase Since 2000, the export of enzyme in China has increased rapidly According to statistics, in 2000, the total export volume of enzymes in China was only 3530 tons, 4812 tons in 2001, and more than 20000 tons in 2008 The export volume of Suzhou Hongda enzyme company alone was more than 5000 tons Why did the export volume of enzymes in China not reach a breakthrough in the 1980s and 1990s when large-scale production of enzymes had been formed, but only increased year after year in the 21st century? The key is that the domestic enzyme production enterprises have adopted the strategy of "borrowing ships to go to sea" According to the data, in the early 1990s, Jiangsu Wuxi enzyme preparation plant, with the output ranking the top three in China, reached a joint venture agreement with geneco, the largest professional enzyme preparation manufacturer in the United States, and set up geneco (China) enzyme preparation company in Wuxi, which quickly aroused the company's strain, fermentation technology and management experience, thus greatly improving the overall situation of Wuxi enzyme preparation plant Output and quantity of export products After genenco, the world's largest enzyme producer, noveide Denmark, also landed in China In 1995, the company established Suzhou Hongda enzyme making company in cooperation with Suzhou (Taicang) Hongda Group It is reported that the company has completed four expansion projects last year, thus becoming the largest enzyme production base in China After the successful introduction of foreign investment, the enzyme production capacity of our country has been greatly improved, and further developed the export market, making the high-quality enzyme produced in our country enter the market of developed countries in Europe and America Importantly, the overall level of enzyme industry in China has been upgraded The general trend of feed use enzyme has developed rapidly in feed additive use in recent years According to statistics, in 2008, the total amount of enzymes used in feed additives in China has exceeded 10000 tons, with a rapid growth rate In recent years, China's export of livestock and poultry meat products have been repeatedly rejected or destroyed by developed countries due to the high antibiotic residues, and China's exporters have also suffered significant economic losses If enzyme is used as feed additive, this kind of situation can be avoided Therefore, enzymes are very popular in feed additives It was found that using enzyme as feed additive can increase feed / meat conversion rate by at least 20%, and can greatly enhance the disease resistance and growth speed of livestock and poultry In the future, it will become a general trend to promote the use of enzymes as animal feed additives It is understood that protease, amylase, phytase, cellulase and lipase are the most popular enzymes for feed additives at home and abroad What's more noteworthy is that "medical enzyme" as a whole product is rising rapidly in developed countries Medical enzyme has become a new industry with annual sales of more than 1 billion US dollars Enzyme for medical use refers to a new enzyme preparation product with therapeutic effect Among them, the medical enzymes that have been developed and put on the market include antibacterial enzyme, fibrinolytic enzyme (such as urokinase, streptokinase, Lumbrokinase, etc.), myxolytic enzyme (which can be used to treat respiratory failure caused by acute emphysema, with a price of up to 1000 US dollars per gram), analgesic enzyme, antitumor enzyme, immune activating enzyme, etc Researchers in Germany and other developed countries have also developed a variety of new products of chiral amino acids necessary for the synthesis of chiral drugs The key lies in the use of a new enzyme named chiral amino acid specific enzyme, which can transform the primary raw materials of racemic amino acids into special amino acid raw materials with single optical isomer, so as to provide more opportunities for the synthesis of chiral drugs Efficient and cheap raw materials In addition, there are a series of new enzymes, such as chitin, which can decompose chitin (chitosan), a natural high molecular weight polymer product of high molecular weight, into a new product of glucosamine with small molecular weight The latter, as a health food for the treatment of degenerative osteoarthritis and rheumatoid arthritis, has a huge demand in the international market at present At the same time, enzyme can also be used as clarifier of aqueous solution of some plant extracts in pharmaceutical production to promote the precipitation of protein impurities In a word, enzymes have already played a more and more important role in modern pharmaceutical production Without the participation of enzymes, many drugs currently in production will not be able to continue to be produced In addition to the pharmaceutical industry, the research of enzyme in medical use is also in-depth Since 1987, enzyme therapy has been gradually popularized and applied in American medical field There are also many countries in Europe following the United States to test the use of medical enzymes for the treatment of patients In addition, researchers have also found some new medical enzymes with great development value, such as "G6PD" which can protect blood cells, prevent leukaemia, and new enzymes which can treat sickle cell anemia It is known that an enzyme from cruciferous vegetables is found to be able to dissolve cancer cells, which is an exciting finding in the increasing incidence rate of cancer and the development of cancer drug development In the medical application, the development trend of breaking enzyme is fast Enzyme has a strong specificity in disease diagnosis, which can help doctors quickly judge the patient's condition and severity About ten diagnostic enzymes have been developed and marketed abroad, such as 5-nucleosidase, α l-fructase, creatinase, special enzyme for the determination of "homocysteine" (a stroke indicator) content in blood, and special enzyme for the determination of HDL / LDL cholesterol content, etc Nowadays, with the development of bioengineering technology, using recombinant DNA to produce medical diagnostic enzyme has become a new industry in developed countries According to F & s data, the total sales volume of enzyme Market (including food, medicine and other industrial enzymes) in the United States has reached 1.8-2 billion US dollars, while the total sales volume of global enzyme market is expected to reach 3.5-4 billion US dollars, in which medical enzymes will occupy a large share Although China has become a big country of enzyme production and export in the world, on the whole, China has not become a strong country of enzyme preparation production, especially in the development and production of medical enzyme preparation, China is far behind the level of developed countries in Europe and America In the future, China's enzyme industry should strengthen the research and development of diagnostic and new enzyme products that are popular in the international market, so as to make a breakthrough in medical enzyme, a promising new product.