Medical College Oncology Hospital Zhang Wei: Don't think it's just an aid, it may affect the whole cancer war.

"The rate of nausea and vomiting is still relatively high during anti-tumor treatment, and I want more people to know that we already have a lot of good anti-spitting drugs and need to explore a more appropriate combination of options that will make patients more comfortable and smoother treatment."
, deputy director of radiotherapy at the Oncology Hospital of the Chinese Academy of Medical Sciences, said in an interview with the media that when chemotherapy is carried out simultaneously, the rate of nausea and vomiting is higher than that of chemotherapy alone.
if you use the following tricks, these adverse reactions can be greatly reduced, "hope to truly achieve a disease-free world, together to win the long-lasting battle against cancer."
first trick: to stop vomiting to be prepared Dr. Zhang Wei reminded that nausea and vomiting and other adverse reactions can occur during chemotherapy.
The risk or degree of occurrence is higher, especially when chemotherapy is conducted simultaneously, and when the area is in the head or abdominal digestive system," the risk of severe vomiting is as high as 60-70%, and even higher in some regions or institutions.
, but if it were pure chemotherapy, it would have a 30-40% rate with the use of a vomit-stopping program."
for patients who use this type of high-spitting tumor treatment program, Dr. Zhang advocates that before treatment is started and nausea and vomiting occur, the anti-spitting program should be prepared in advance.
Because as long as there has been vomiting, this feeling may be difficult to eliminate for many days, and even some people will form psychological condition reflexes, such as seeing the treatment-related words want to vomit, walk to the hospital door want to vomit, or hear the nurse push the sound of the treatment car will want to vomit.
"but where there is a vomiting, the patient's tolerance and compliance with tumor treatment will be greatly affected."
we generally do these preventive treatments in advance.
it's not easy to stop it when it doesn't happen, and it's not the same as stopping it when it happens, " Dr. Zhang said.
Currently, the anti-spitting guidelines for chemotherapy at the same time refer to the anti-spitting guidelines for pure chemotherapy drugs, which divide the treatment plan into high, medium and low risk of vomiting, and carry out different preventive treatment in advance according to different levels and degrees.
high-spitting program will use triple drugs, namely NK-1 inhibitors, 5-serotonin blockers plus hormones, in addition to some stability class, oxycodone class of psychostation drugs, at the same time use.
Zhang Wei, the triple program makes the occurrence of vomiting significantly decreased, especially the occurrence of severe vomiting is very low.
that the rate of severe vomiting can be controlled at about 10%, far lower than the original.
, triple drugs also reduced the risk of severe nausea to 30-40%.
The second trick: strike to be precise and comprehensive" We can reduce the risk of high vomiting to 10% or less, so that 10 out of 10 patients can complete the course of chemotherapy within a relatively to bearable range.
it is important to remember that this is a joint use of triple anti-spitting drugs in the current guidelines.
" Dr. Zhang Stressed that although there are currently very effective anti-spitting drugs, but to play the best effect, the use of methods are also exquisite.
the occurrence of nausea and vomiting reaction was first found to be related to the gastrointestinal tract 5-serotonin inhibitor, so the emergence of 5-serotonin blocker, but also significantly reduced the occurrence of nausea and vomiting in patients at that time.
But it was later discovered that it was actually related to P-matter in intracranial brain tissue, and further studies found a relationship with NK-1 subjects, followed by the emergence of NK-1 inhibitors or blocker drugs.
" this is equivalent to hitting a snake seven inches, the same is true of vomiting, although the gastrointestinal symptoms are called vomiting, but it is more and the central control of the regulation.
If it is a headache doctor head and foot pain doctor foot, a lot of times is the cure, that is to say, for high vomiting, especially platinum drugs, you also just simply use 5-serotonin blocker combined with symesone, the effect of anti-spitting is not too good, so it is best to add NK-1 subject inhibitors."
Of course, this does not mean that a drug in the triple drug "only I respect", Dr. Zhang said, in fact, the triple program is complementary "three swordsmen", each shouldering its responsibilities in the battle to supplement each other's loopholes, to do more close protection.
On the other hand, clinicians and scientists are constantly upgrading the "three swordsman" combination, for example, some explorations have found that hormones play a less important role in this, and in the past studies have found that ono-nitrogen, stability has a certain effect on the rate of nausea.
to replace hormones with tyrogens to form a new "three swordsmen" is also a possibility for the future.
Threeth trick: ammunition to ensure adequate effect" If the patient because of nausea and vomiting these adverse reactions, weight loss, poor nutritional status and so on, this is equivalent to the war, ammunition grain and grass shortage, logistics can not keep up, how can win? In many cases, the completion rate and dose of chemotherapy during radiation therapy are related to the efficacy of the entire tumor treatment, Dr. Zhang said.
, it is necessary to ensure that anti-tumor drugs in a certain period of time to give a certain dose, in order to achieve a good therapeutic effect.
But if there is a more severe reaction during simultaneous chemotherapy, the dose intensity of the chemotherapy drug given will be reduced and reduced, which will lead to a decrease in the intensity of tumor treatment, the effectiveness of cancer treatment will certainly be reduced.
On the other hand, if the incidence of nausea and vomiting is particularly high during treatment, especially in the head and neck tumors, esophageal cancer, gastrointestinal tumors of this part of the patients, their nutritional function, digestion and absorption function will be greatly reduced, which will lead to weight loss and poor nutrition, it is more difficult to win the long-lasting battle against tumors.
" so throughout the treatment process, I must ensure a certain intensity of chemotherapy into the line, anti-spitting program to win this battle is a very important help, if this link off the chain, may even lead to the failure of the entire anti-tumor treatment.
is an auxiliary link, it can also affect the whole war situation.
" That is why Dr. Zhang called for better policy support to promote universal access to primary health care workers, patients and their families, so that everyone knows that chemotherapy and radiotherapy are not as difficult as they seem, but can actually complete the treatment process in relative comfort.
Expert Introduction Dr. Zhang Wei, Deputy Director of Radiotherapy Department, Cancer Hospital, Chinese Academy of Medical Sciences Source: 39 Health Network Copyright Notice: All text, pictures and audio and video materials noted on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine, are not authorized, and any media, website or individual may not reproduce them, and shall indicate "Source: Meis Medicine" when authorizing their reprint.
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