Medical circles call for elimination of Chinese and Western medicine Giant Guizhou bailing is in danger

Experts in the medical community called for the elimination of Chinese and Western medicine compound preparations through legislation; more than half of Guizhou bailing's revenue came from the combination of Chinese and Western medicine Recently, a vitamin C Yinqiao tablet suspected to be produced by Tong'an pharmaceutical company in the mainland was found to contain "illegal ingredients" in Hong Kong According to the investigation and clarification of the State Food and drug administration, the involved drugs are not the Weic Yinqiao Tablets produced by Tongan pharmaceutical industry However, the attention caused by VEC Yinqiao Tablets has not dissipated According to reports, in an MSN health survey involving more than 1000 netizens, 37% of the participants stated that they were still worried about the vitamin C Yinqiao tablet and would not take it for the time being In the academic circle of medicine, the "original sin" of "compound preparation of Chinese and Western medicine" with vitamin C Yinqiao tablet as a typical one has also been raised by many experts again Some consumers said that there are so many problems in the traditional Chinese and Western medicine compound preparation which is "safer than western medicine and more effective than traditional Chinese medicine" "We don't comment on the opinions and appeals of experts As a pharmaceutical manufacturer, we produce and manufacture according to national standards From this point of view, I think there is no problem," he said in an interview with the Beijing News Is "compliance" of Yinqiao tablet equivalent to "safety"? It is suspected that the "illegal ingredients" of Weic Yinqiao tablet in Hong Kong made the risk of Weic Yinqiao tablet concerned again On June 19, the Hong Kong Department of Health said that the vitamin C Yinqiao Tablets produced by Tong'an pharmaceutical, a mainland pharmaceutical company, had been detected to contain two unmarked and banned western medicine ingredients, namely "phenacetin" and "aminopyrine", calling on consumers not to buy or take them Tongan pharmaceutical is directly involved, but Guizhou bailing, A-share listed company, is the most nervous According to statistics, more than half of the VC Yinqiao films on the market come from this company After the news, Guizhou bailing's stock price fell more than 4% on that day, and fell 3.3% at the end of the day In Guizhou bailing stock bar, a shareholder exclaimed: "if Wei C (Yinqiao piece) is hung, what else does bailing have?" On the evening of June 19, Guizhou bailing issued a clarification notice: the vitamin C Yinqiao tablet produced by the company "is produced in strict accordance with the relevant national standards, and does not contain any other ingredients other than the drug prescription" And said that the company has a sound quality control system, from raw material procurement and testing, product processing to the production of finished products in all stages are compliant, "the company's procurement of Chinese and Western raw materials are high-quality varieties." Does "compliance" mean "safety" and does "quality" mean "effectiveness"? Xu Zheng, a professor at West China College of medicine, Sichuan University, told the Beijing news that as an over-the-counter Chinese and western compound drug, the risk of Weic Yinqiao tablet has been recognized by the pharmaceutical industry It is understood that according to the Pharmacopoeia, "compliance" vitamin C Yinqiao tablet is a combination of three Western medicines, chlorphenamine maleate, paracetamol and vitamin C, on the basis of the traditional Chinese patent medicine "Yinqiao Powder" However, only vitamin C and forsythia can appear in the drug name Two Western medicines, chlorphenamine maleate and paracetamol, have been deprived of the "right of signature" Therefore, the fact that Yinqiao tablet contains two western medicine ingredients is not well known to ordinary consumers A community doctor told reporters that he has been a doctor for more than ten years, and most of the patients and ordinary people who are in daily contact with him know that "Chinese medicine with vitamin C added" and "eating is not bad" Therefore, even if the dosage is indicated in the drug manual, not a few people will take it arbitrarily In addition, the impression of "clearing heat and eliminating fire" of vitamin C Yinqiao tablet is deeply rooted in people's hearts, "many people not only have a cold to eat, their throat is uncomfortable to eat, but also have to eat if there is a acne on their face." The doctor said, "I can't explain it to everyone around me in detail Every time I tell them, don't take it without illness," it's three poisons of medicine " But people's vigilance to this drug is still unbelievably low " According to the case report database of national ADR monitoring center, from January 1, 2004 to April 30, 2010, there were 1885 pathological reports of Weic Yinqiao Tablets and 48 serious pathological reports The adverse reactions mainly involve the central and peripheral nervous system, digestive system, skin and appendages, and even lead to urticaria Experts believe that the above adverse reactions of Yinqiao Tablets are actually in the normal range, but the problem is that as OTC (over-the-counter drugs), the risks of Yinqiao Tablets are not understood by ordinary consumers On September 19, 2010, the State Food and Drug Administration issued the 32nd notice on adverse drug reactions, reminding medical workers, drug production and marketing enterprises and the public to pay attention to the safety of the compound preparation of Chinese and Western medicine, Weic Yinqiao tablet, in order to reduce the risk of drug use "Weic Yinqiao tablet contains paracetamol, which is the antipyretic and analgesic component of Western medicine If it is used in a single way or in combination with western medicine, excessive use will lead to liver damage There have been problems in the UK, and some experts have even asked to disqualify it as an over-the-counter public drug " Xu Zheng, a professor at West China College of medicine, Sichuan University, told reporters Acetaminophen overdose is reported to be an important cause of acute liver failure in the United States In the United States, 56000 people are sent to the emergency room every year, and about 200 of them die "Chinese and Western medicine compound preparation" was criticized as "vitamin C Yinqiao tablet" just the fuse The "compound preparation of Chinese and Western medicine" represented by Weic Yinqiao tablet has become a new object of question According to the article, there is no theoretical basis for modern medicine and pharmacology, nor can traditional Chinese medicine be used to explain the compound preparation of Chinese and Western medicine The compound preparation of Chinese and Western medicine does not meet the standards of traditional Chinese medicine and chemical medicine The study of drug interaction is almost blank According to the data, in September 2010, the State Food and Drug Administration issued the notice of adverse drug reaction information to remind people of the safety of the compound preparation of Chinese and Western medicine, Weic Yinqiao tablet In September 2011, the Hong Kong Department of health found in a routine market surveillance that Baiyunshan Ganmaoqing capsule contained trace acetaminophen, a antipyretic drug, which was recalled due to the violation of laws and regulations by adding Western ingredients to traditional Chinese medicine In October 2011, Hong Kong ordered the recall of a Chinese patent medicine named xiaozhixinkangbao, which contains two Western medicines, losartan and atorvastatin In March 2013, the State Food and Drug Administration issued the notice of adverse drug reactions, which reported that the adverse reactions of Zhenju hypotensive tablet were mainly related to its chemical composition, and the proportion of serious adverse reactions increased when combined use The U.S Food and Drug Administration banned the import of Chinese patent medicines containing chemicals in its 1991 import warning notice, and the EU botanical drug registration act also banned the addition of chemicals to botanical medicines "Chinese and Western medicine compound preparation", which is not popular in Hong Kong and even in the world, has been popular in China for many years It is understood that among the more than 5000 kinds of Chinese patent medicines included in the new national patent medicine, there are about 200 kinds of Chinese and Western medicine compound preparations, most of which are OTC varieties, mainly concentrated in three categories of drugs, including anti cold drugs, cough and asthma drugs, gastrointestinal drugs, etc The western medicine mainly includes chlorpheniramine, paracetamol, ephedrine, diphenhydramine, vitamin C, etc In addition, most traditional Chinese medicine cold medicines contain caffeine and other stimulants In the cold medicine market alone, there are 18 kinds of Chinese and Western medicine compound preparations, all of which are OTC This kind of medicine has a large share in Chinese medicine market 999 Ganmaoling of China Resources Sanjiu achieved a sales volume of 1.46 billion yuan in 2012; in 2012, Guizhou bailing produced and sold 8 billion Weic Yinqiao Tablets, with an output value of 260 million yuan; Xiaoke pill, the exclusive product of Guangzhou Pharmaceutical Group, with a sales volume of more than 600 million yuan in 2012; in 2012, Shenzhen tonganwei Yinqiao tablet achieved a sales volume of 50 million yuan, accounting for 50% of the company's overall revenue "Traditional Chinese medicine (ingredients) is responsible for profits, while western medicine (ingredients) is responsible for curative effect." Someone made this summary of "Chinese and Western medicine compound preparation" on Weibo "Combination of Chinese and Western medicine" contributes more than half of the revenue to bailing, and it contributes half of the revenue to Guizhou bailing According to the public information, most of the main business income of Guizhou bailing comes from the steady growth of "four King Kong" (Kesu stop series, Weic Yinqiao tablet, Jingan capsule and Yindanxinnaotong) Among the "four King Kong", two "Star" drugs, Weic Yinqiao tablet and Jingan capsule, contributed more than half of the company's revenue According to the data, in 2011, the market sales of Guizhou bailingwei C Yinqiao tablet was 361 million yuan, ranking fourth in the domestic market of "cold oral Chinese patent medicine"; the sales of Jingan capsule reached 211 million yuan, ranking seventh in the market of cold oral Chinese patent medicine in China In 2011, the turnover of Guizhou bailing was 1.16 billion yuan The total sales of the above two cold medicines account for half of the total revenue of Guizhou bailing In other words, the two drugs that contribute half of the company's revenue are both Chinese and Western medicine composite preparations At the same time, Guizhou bailing seems to see more good things In the public report, the factory self analyzed that "as Weic Yinqiao tablet and Jingan capsule belong to the combination of Chinese and western cold medicine, Jingan capsule and Weic Yinqiao tablet belong to OTC (over-the-counter medicine) products, we can use the existing mature marketing network of Weic Yinqiao tablet to expand the sales of Jingan capsule through marketing channels, saving costs and expenses." At the same time, "the price of Jingan capsule is higher than that of VC Yinqiao tablet, which can give dealers more profit space, and the growth rate is expected to be 30% in the next few years." Compared with VEC Yinqiao tablet, Jinguan capsule is a drug independently researched and developed by the company, which is an exclusive product with invention patent It has differentiated competition with existing cold drugs in the market, with a slightly lower degree of competition Its independent pricing space is large, and its gross profit has been maintained at more than 75% " As early as the IPO of Guizhou bailing in 2010, it has done a good job to expand the plan of Weic Yinqiao film During the IPO roadshow, investors asked why the company continued to expand its low margin production line of VC Yinqiao Tablets Jiang Wei, chairman of the company, replied: "Wei C Yinqiao tablet is cheap and good in quality, which is popular with middle and low-level consumers, so it must be produced." According to the data, in 2007, Guizhou bailing was not listed At that time, 70% of the company's revenue came from three major cold medicines: keshiding syrup, Weic Yinqiao tablet and Jingan capsule In 2009, Guizhou bailing's Weic Yinqiao tablet successfully achieved 48.4% market share with a sales volume of RMB 606 million; by 2012, the market share has reached more than 50% Chinese and Western medicine compound preparation or towards elimination the state drug regulatory department has long stopped approving the listing of new Chinese and Western medicine Many experts call for the elimination of Chinese and Western medicine that still exists on the market "Traditional Chinese medicine is traditional Chinese medicine, western medicine is western medicine In the future, we should separate these two kinds." Wu Qinggong, vice president of China Pharmaceutical Enterprise Management Association, told the Beijing news that integrated Chinese and Western medicine, as a product of long-standing controversy and lack of rigorous experimental proof, should be eliminated through legislation in the future According to Xu Zheng, a professor at West China College of medicine, Sichuan University, the emergence and retention of "Chinese and Western medicine compound preparation" is a "historical problem" It is understood that in the 1950s, there was a trend of integration of traditional Chinese and Western medicine in the medical field of mainland China The compound preparation of traditional Chinese and Western medicine is convenient for the birth of this year