Med Oncol: Serotonin and vitamin E reduce the severity of oral mucositis and swallowing difficulties in cancer patients with head and neck due to radiotherapy

The purpose of this study was to assess the effects of serotonin and vitamin E on the incidence and severity of oral mucositis and swallowing difficulties caused by radiation therapy in patients with head and neck cancera prospective randomized controlled study included patients with head and neck cancer who received 30-35 radiotherapy types, accompanied by or inconsistent chemotherapy, and excluded those who were not tolerant of jaundice and had any tendency to bleedselected 60 patients, 30 patients received radiotherapy (control group), 30 patients received radiotherapy with serotonin and vitamin E (intervention group)Assess the incidence, severity, morbidity and duration of oral mucositis and/or swallowing difficultiesRecord and compare local control, quality of life, hospitalization needs, radiotherapy gaps and adverse events between groupsresults showed that the use of serotonin and vitamin E did not affect the incidence and incidence of oral mucositis and/or swallowing difficultiesAfter age correction, the combination reduces the incidence of severe oral mucositis (P s 0.01) and difficulty swallowing (P s 0.012)This combination reduces the duration of oral mucositis and swallowing difficulties by 5 weeks (p - 0.002) and 4 weeks respectively (p s 0.003)Research drugs reduced the need for hospitalization (p - 0.002) and the need for radiation rest (p - 0.002), and the FOIS (p - 0.014), the EQ-5D index (p - 0.009) and the VAS score (p s 0.012) improvedSerotonin and vitamin E reduce the occurrence of diaphmotic barriers (p s 0.026) and fatigue (p s 0.026) without affecting area controlin general, the combination of pentahydroxymethamphetamine/vitamin E reduces the severity and duration of oral mucositis and swallowing difficulties caused by acute radiotherapy in patients with head and neck cancer