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The ketogenic diet (KD) is a high-fat, low-carbohydrate diet with appropriate protein and other nutrients
.
When people are on a ketogenic diet, the body metabolizes more ketone bodies (including acetoacetate, beta-hydroxybutyrate, and acetone) to use as a source of energy
.
The ketogenic diet (KD) is a high-fat, low-carbohydrate diet with appropriate protein and other nutrients
Pancreatic cancer is a malignant tumor of the digestive tract with a high degree of malignancy, which is difficult to diagnose and treat
Joshua Rabinowitz Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth
The study found that a ketogenic diet combined with chemotherapy disrupted the metabolism and growth of pancreatic cancer cells, making tumors more sensitive to chemotherapy and three-fold longer survival in mouse models of pancreatic cancer
.
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Numerous early studies have shown that fasting can enhance the treatment of many types of cancer
.
For the study, the researchers created a mouse model of pancreatic ductal adenocarcinoma, the main type of pancreatic cancer, and fed the mice a normal carbohydrate-rich diet or a ketogenic diet and received standard chemotherapy
.
The researchers found that the ketogenic diet alone did not affect tumor growth
.
However, when the ketogenic diet was combined with chemotherapy, the average survival time in the mouse model tripled
.
In addition, the researchers analyzed the effect of the combination therapy on tumor metabolism
.
The study found that the ketogenic diet lowered glucose levels in tumors more deeply and significantly suppressed insulin levels compared to healthy tissue
.
Compared to healthy tissue, the ketogenic diet lowered glucose levels more deeply in tumors and significantly suppressed insulin levels
A ketogenic diet forces the body to break down fat to create ketone body molecules, which can be burned by cells to produce energy
.
Ketogenic diet inhibits tumor glucose utilization and induces 3-hydroxybutyrate burning
Ketogenic diet inhibits tumor glucose utilization and induces 3-hydroxybutyrate burning Ketogenic diet inhibits tumor glucose utilization and induces 3-hydroxybutyrate burningThis excess of electrons leads to the production of reactive oxygen species (ROS), which are extremely unstable molecules that chemotherapy also produces
.
Reactive oxygen species kill cancer cells by damaging their DNA, cell membranes and other components
.
The findings are exciting, the researchers say, and the benefits of a ketogenic diet combined with chemotherapy have now been seen, at least in mice
.
We will further explore its effects in humans next
.
Original source:
Original source:Lifeng Yang, et al.
Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth .
Med, VOLUME 3, ISSUE 2, P119-136.
E8,
