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Mechanisms of monkeypox virus DNA synthesis

 Last Update: 2022-12-30
 Source: Internet
 Author: User

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Using cryomicroscopy, the researchers demonstrated the high-resolution structure of monkeypox virus DNA polymerase holase, a complex that plays a key role in viral genome replication
.
This discovery reveals the mechanism of monkeypox virus genome replication and can be used to guide the development of
antiviral drugs.
In July 2022, the World Health Organization declared monkeypox virus (MPXV) a Public Health Emergency of International Concern (MPXV), and as of early December 2022, more than 82 000 human monkeypox cases
have been confirmed in 110 countries around the world.
New preventive and therapeutic measures
are needed for this virus.
In this study, Qi Peng and colleagues used cryo-electron microscopy to determine the high-resolution structure
of monkeypox virus DNA polymerase holase.
According to the findings, the holoenzyme has a structure that indicates the "forward sliding clamp" mechanism
for DNA replication.
The authors believe that this discovery could be used to design anti-acne virus drugs
.

Structure of monkeypox virus DNA polymerase holoenzyme

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