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Researchers from the Institute of Industrial Science at the University of Tokyo have recently discovered that the infection of the measles virus activates two different branches of the innate immune system instead of one
This result was recently published in "PLOS Pathogens" magazine, revealing a new host defense strategy, which is expected to help people completely eradicate this infectious disease
Measles is one of the most common acute respiratory infections in children
The team recently discovered that infection by the measles virus (MeV) causes the activation of RNA and DNA viral immune responses
After measles virus infection, mitochondrial DNA is released into the cell
Hiroki Sato, the first author of the article, said: “We first used imaging technology to find mitochondrial abnormalities in cultured cells infected with measles
This is the first time that single-stranded and negative-stranded RNA viruses can activate the cGAS pathway
The research team then found evidence from previously published data sets that other viruses that affect mitochondrial growth and development can also trigger this response
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Sato H, Hoshi M, Ikeda F, Fujiyuki T, Yoneda M, Kai C (2021) Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase.
