MCP: How does cancer spread? Scientists identify key genes that affect communication between cancer cells!

How does cancer spread? In a recent study published in the international journal Molecular and Cellular Proteomics, scientists from McGill University answered important questions about the spread of cancer by studying tumor cells in the human brain; researchers studied a gene called EGFRVIII, which is found mainly in the body of patients with glioblastoma, a rapidly spreading malignant brain tumor that is often difficult to treat.
the study, researchers delved into how cancer-causing genes, such as cancer gene EGFRvIII, alter the content of information exchanged between cells, and researcher Dr Janusz Rak said cancer cells attack us in groups, but if they want to work together Cancer cells must communicate with each other; one way is through a tiny vesicle structure called an extracellular vesicle (Evs) or exosome, which is usually filled with active proteins that act as shuttle messengers between cells.Gens that make cells speak different languages
The researchers found that cancer-inducing cancer gene EGFRvIII also allows cells to "speak different languages" and that proteins in extracellular cysts can alter cell behavior, such as allowing cells to invade tissues or spread. As extracellular follicles transmit proteins between different cells, some of them are thought to be invasive signals that make up an important part of cancer;to block cell-to-cell communication to fight cancer
the findings may help scientists develop new ways to stop the spread of cancer by blocking the transmission of information about extracellular vesicles between different cancer cells. 'This study suggests that different cancer genes may have different effects on cell-to-cell communication, as well as on the types and contents of extracellular vesicle structures released or received by cancer cells, so we need to understand the molecular mechanisms involved to develop new cancer-specific therapies,' said researcher Dr. Dongsic Choi.
researchers were able to detect the presence of extracellular vesicles in blood samples, so they could be used to diagnose cancer in this way; the proteins found by researchers in extracellular vesicles could lead to new diagnostic strategies or new treatments for glioblastoma. Polygonal glioblastoma is very prevalent among people between the ages of 45 and 70 and has the worst prognosis of any type of cancer; about 1,000 Canadians are diagnosed with glioblastoma each year, and only 4 percent survive for five years or more, and researchers still don't know the molecular mechanisms that induce glioblastoma.
later this year, researchers hope to develop new individualized diagnostic techniques or strategies that can effectively treat glioblastoma based on the results of this paper. (Bio Valley)