mBio: Live vaccine helps prevent lung inflammation in patients with COVID19

, July 2, 2020 /PRNewswire/ --- DrPaul Fidel, professor at the New Orleans School of Dentistry at LSU Health, and DrMairi Noverr, professor of microbiology and immunology, have recently shown that detoxifying live vaccines, such as measles, mumps and rubella, can prevent severe lung inflammation and sepsis associated with COVID-19 infectionsThe paper was recently published in the journal mBioincreasing evidence that a detoxifying live vaccine activates nonspecific immune cells to train white blood cells (the immune system's white blood cells) to protect against unrelated infections more effectivelyThe researchers have shown in the lab that vaccination with a detoxifying live strain can produce a congenital protective effect against pathogenic sepsis (blood poisoning)(picture:authors suggest that the protection of a live vaccine free from long-term infections is produced by a long-standing myelin-derived inhibitory cell (MDSC), which has previously been shown to suppress sepsis inflammation and mortality in a variety of experimental modelsThey stressed that the concept of this detoxifying MMR vaccine is by no means recommended for COVID-19, but rather for the severe inflammatory symptoms of COVID-19similar concepts are being tested in other countries"In Europe, Australia and the United States, at least six clinical trials were conducted to test the bGBColihine (live detox) vaccine or placebo vaccination in high-risk health care providers to determine whether it is beneficial to produce a trained innate response to COVID-19," the authors wrote"
contrary to the idea that the innate responses after training include inducing MDSCs, which inhibit/reduce severe lung inflammation/sepsis associated with COVID-19," said Fidel and NoverrAlthough we have initiated clinical trials and animal model studies to verify the hypothesis that an MMR vaccine given to adults induces our recommended bystander cells to suppress severe pulmonary inflammation/sepsis associated with COVID-19 infection, we recommend that adults should be vaccinated against MMR/strengthened vaccines in the absence of low immunity, pregnant women, or people at high risk of vaccine allergies Fidel concludes "If we're right, people who get the MMR vaccine will suffer less if they're infected with COVID-19, " he said If we are wrong, then the person's immunity to measles, mumps and rubella will be better This is a harmless suggestion " (Bio Valley Bioon.com) Source: Live attenuated vaccines may meth o'r lung and sepsis covid-19
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doi.org/10.1128/mBio.00907-20.