Market Quotes of Pharmaceutical Grade Glycerol Glycerol Pharmaceutical Excipients Lubricant

Chinese name Glycerin English name Glycerin alias Glycerin trihydroxypropane glycerin crude glycerin English alias 1,2,3-propanetriol1,2,3-TrihydroxypropaneD-glycerolglycyl alcoholGlycerin mistglyceritolGlycerolL-glycerolPolyhydric alcoholsPropanetrioltrihydroxypropaneGlycerinepropane-1,1,1-triolCAS56-81- 5EINECS200-289-5 Chemical formula C3H8O3 Molecular weight 92.
0938InChIInChI=1/C3H8O3/c1-2-3(4,5)6/h4-6H, 2H2,1H3 Density 1.
303g/cm3 Melting point 18°C ​​Boiling point 98.
3°C at 760 mmHg Flash Point 22.
9°C Water solubility>500 g/L (20°C) Vapor pressure 23.
2mmHg at 25°C Refractive index 1.
492 Physical and chemical properties Colorless, transparent, odorless, viscous liquid, sweet taste, hygroscopic
.

The solubility is miscible with water and ethanol, and the aqueous solution is neutral
.

Dissolved in 11 times ethyl acetate
.

Insoluble in benzene, chloroform, carbon tetrachloride, carbon disulfide, petroleum ether, oils
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Glycerol - The standard product is 1,2,3-propanetriol
.

Calculated on anhydrous basis, the content of C3H80 3 shall not be less than 95.
0%
.

Glycerol - production method After the industrial glycerin is diluted with an appropriate amount of water, it is purified by ion exchange, then vacuum distillation and dehydration, adding activated carbon for adsorption and decolorization, and filtering and removing the activated carbon
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This product is colorless, clear viscous liquid; sweet in taste; hygroscopic; aqueous solution (1-10) shows neutral reaction
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This product can be miscible with water or ethanol at will.
Relative density The relative density of this product (general rule 0601) is not less than 1.
257 at 25 t
:.

Refractive index The refractive index of this product (general rule 0622) should be 1.
470~1.
475
.

Glycerol - Uses Gas Chromatography Fixative
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Measure boron complexing agent
.

Used as solvents, lubricants, cosmetic formulations and in the pharmaceutical industry
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Glycerol - The infrared absorption spectrum to identify this product should be consistent with the control spectrum (spectral set 7 and 7)
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Glycerol - Check pH, take 25.
0g of this product, add water to dilute to 50ml, mix well, add 0.
5ml of phenolphthalein indicator solution, the solution should be colorless, add 0.
2 ml of 0.
1 mol/L sodium hydroxide solution, the solution should be pink color
.

Take 50ml of this product for color, put it in a 50ml Nessler colorimetric tube, and compare it with the reference solution (take 0.
2 ml of potassium dichromate solution for colorimetry, and dilute to 50ml with water), it should not be deeper
.

0015%)。 Chloride to take this product ≤ 0 g, check according to law (general rule 0801), compared with the control solution made of standard sodium chloride solution 7.
5ml, should not be more concentrated (0.
0015%)
.

Take 10g of this product for sulfate and check it according to the law (General Rule 0802).
Compared with the control solution made of standard solution 2.
Oral, it should not be more concentrated (0.
002%)
.

Aldehyde and reducing substances take about 1g of this product, put it in a 50ml measuring bottle, add 25ml of water to dissolve, add a newly prepared 10% saline solution (adjust the pH value to 4 with 0.
02mol/L sodium hydroxide solution) .
0
.

(Newly prepared) 2ml and let stand for 30 minutes, add 5ml of newly prepared 0.
5% ferric chloride solution, shake well, let stand for 5 minutes, add methanol to dilute to the mark, and shake well
.

According to ultraviolet-visible spectrophotometry (general rule 0401), measure the absorbance at the wavelength of 655nm, the absorbance of the test solution shall not be greater than the reference solution [every 1 ml contains formaldehyde (CH20) 5.
0Mg] 2.
0 ml with the same method Absorbance after treatment
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Extract 5.
0 g of this product, add 5 ml of water, mix well, 1, put it on a water bath to heat for 5 minutes, add 3 ml of 2xnol/L sodium hydroxide solution without carbonate, add 1 ml of copper sulfate test solution dropwise, Mix well, it should be a blue clear solution, continue to heat on the water bath for 5 minutes, the solution should still be blue, no precipitation
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Fatty acids and lipids take 40g of this product, add 40ml of freshly boiled cold water, and then add 10ml of sodium hydroxide titration solution (0.
ltn ol/L) precisely, after shaking, boil for 5 minutes, let cool, add phenolphthalein indicator solution A few drops were titrated with hydrochloric acid titration solution (0.
1 mol/L) until the red turtle disappeared, and the titration result was corrected with a blank test
.

The consumed sodium hydroxide titrant (0.
1 mol/L) shall not exceed 4.
0ml
.

Take 4.
0g of this product for easy carbonization, drop 5ml under shaking, and control the temperature not to exceed 20 °C during the process.
0.
2ml, compared with 1.
6ml of potassium dichromate solution and 8.
2ml of water for colorimetric comparison, it shall not be deeper
.

The moisture content of this product is measured according to the moisture determination method (General Rule 083), and the moisture content shall not exceed 2.
0%
.

Take 20.
0g of this product from the residue on ignition, heat it to spontaneous combustion, stop heating, let it cool after the combustion is complete, and inspect it according to the law (general rule 0841), and the remaining residue should not exceed 2mg
.

Take 4.
0 g of this product as ammonium salt, add 5 ml of 10% potassium hydroxide solution, mix well, and place it at 60°C for 5 minutes, without ammonia odor
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Take 10.
0 g of this product from iron salt, check it according to the law (general rule 0807) and compare it with the control solution made of 2.
0 ml of standard iron solution, and it should not be deeper (0.
0002%)
.

Take 5.
0g of this product for heavy metals and inspect it according to the law (General Rule 0821), and the heavy metal content shall not exceed 2 parts per million
.

Take 6.
65g of this product as arsenic salt, add 23ml of water and 5ml of hydrochloric acid, mix well, check according to the law (the first method of General Rule 0822), and it should meet the regulations (0.
000 03%)
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 Glycerol - Determination of glycerol content Take about 0.
1 g of this product, accurately weigh it, add 45 ml of water, mix well, accurately add 2.
5 ml of 2.
14% sodium periodate solution, shake well, place in a dark place for 15 minutes, add 5 10 ml of 0% (g/ml) ethylene glycol solution, shake well, place in the dark for 20 minutes, add 0.
5 ml of phenolphthalein indicator solution, and titrate to red with sodium hydroxide titration solution (0.
1 mol/L), The color does not fade within 30 seconds, and the titration result is corrected with a blank test
.

Each 1 l sodium hydroxide titration solution (0.
1 mol/IJ is equivalent to 9.
21 mg of C3 H80 3
.

Glycerol - class of pharmaceutical excipients, solvents and suspending agents, etc.

Glycerol
- storage sealed and kept in a dry place
.