Map study reveals the interaction chain between proteins

Science and technology daily, Beijing, Sept 8 (reporter Liu suihan) an international research team has found through large-scale protein mapping research that different proteins in organic biological cells have deep connections, and it is their interaction that promotes the construction of cells and organisms And the mapping of protein map can help scientists to explore the causes of various diseases that lead to the complexity of human beings The study was led by Professor Andrew Emily of the University of Toronto in Canada and Professor Edward markot of the University of Texas at Austin in in the United States Seven research teams from three countries participated in the study According to the physicist's organization network, researchers carefully screened the data extracted from nine representative organisms in the evolution of life, including yeast, worms, mice and humans, to reveal how different proteins interact with each other, so as to jointly build cells and organisms Proteins are the undertakers of a lot of work in cells Many proteins adhere together to form a "molecular machine", which can perform tasks together to make new proteins, or grind and recycle unused proteins With the help of advanced methods, researchers have captured thousands of "molecular mechanisms" from cells, isolated the single proteins that make up them, and drawn a detailed protein map Through this map, unknown proteins can be deduced from proteins with known functions Based on these data, the researchers found tens of thousands of protein interactions According to statistics, about a quarter of the proteins in the cell are related to each other, even if only one protein is lost in the interaction chain, it will lead to disease The study found that the interaction of more than 10000 proteins had not changed since the early days of cell birth a billion years ago Professor Emily estimates that there are more than one million protein interaction chains in the whole animal kingdom The research materials will be open to researchers all over the world The protein map may be able to accurately find out the causes of some human diseases, so this map may help scientists to identify which proteins are the causes of various complex human diseases Professor Emily said: "in the future, as more protein interactions are found, our map will provide more clues about the relationship between proteins and diseases." The research was published online September 7 in nature.