Many articles interpret the new achievements of scientists in the study of inflammatory diseases!

In recent years, scientists have made many achievements in inflammatory disease research through a large number of studies In this paper, the editor will sort out the relevant important research results and share them with you! Photo source: cc0 public domain [1] NAT Immunol: good things turn into bad things, over active immune cells may cause body inflammation doi: 10.1038/s41590-019-0482-2 recently, an international journal Nature In the Research Report on immunology, scientists from Basel University and other institutions described a previously unknown immune system disorder through research In a subpopulation of immune cells of patients with primary immunodeficiency, the respiratory rate of cells will increase significantly, and excessive metabolic activity will often lead to inflammation The immune system can protect the body against infection and tumorigenesis, which is a very challenging task, especially because it is necessary to avoid damaging the body's own healthy tissues at the same time However, rare heredity Sexual diseases can cause immune system defects, i.e primary immune system defects (PID) One of the consequences of this disease is that patients are very vulnerable to infection However, specific tumors and non infectious inflammation may occur more frequently 【2】 Nature: breakthrough! Scientists have found a new type of human inflammatory disease CRIA syndrome! Doi: 10.1038/s41586-019-1828-5 recently, in a research report published in the international journal Nature, scientists from Walter and Eliza Research Institute and other institutions in Australia have identified the inheritance of a previously unknown human autoimmune disease (AID) through research For this reason, researchers call this kind of autoimmune disease CRIA syndrome (cleavage resistant ripk1 induced autoinflammation), which is induced by mutation of a key cell death component Lalaoui said that in this study, we identified a new type of human inflammatory disease, and also found that a key mutation related to cell death molecules drove the occurrence of this disease Cell death pathway will develop a series of built-in mechanisms to regulate inflammatory signals and cell death In the process of disease occurrence, ripk1 mutation will overcome all existing normal check and balance mechanisms, thus inducing cell death and inflammation out of control 【3】 Cell metal: to identify a new target that can effectively treat human inflammatory diseases doi: 10.1016/j.cmet.2019.10.004 recently, a research report published in the international journal Cell metal, scientists from the University of Birmingham and other institutions identified a potential new target for the treatment of inflammatory diseases through research Researchers are good at studying cell metabolism, that is, a series of chemical reactions or a series of metabolic pathway signal transduction in order to maintain life In this paper, the researchers focus on how lactate mediates the immune system's response to inflammation Lactate is a special molecule produced by most tissues of human body, which produces the largest amount in muscle, and the level of lactate in blood is regulated by the kidney The high level of lactate in blood means that disease or other conditions will promote the accumulation of lactate In general, the increase of lactate level means that the severity of the disease has increased Moreover, clinicians can use the lactate level of patients' body to monitor their health and recovery in real time 【4】 Nature: insomnia can interfere with the intestinal health of the body and cause a variety of health problems such as inflammatory bowel disease doi: 10.1038/s41586-019-1579-3 As we all know, people who often work night shift or travel across different time zones are more likely to become obese or suffer from intestinal inflammation At present, researchers do not know the specific molecular mechanism Recently, a study published in the international journal Nature found a group of type 3 natural lymphocytes closely related to intestinal health in the gut by scientists from grape teeth (ilc3s, group 3 intrinsic lymphoid cells) may be regulated by the circadian clock of the brain Sleep deprivation or changing sleep habits will have serious consequences on the health of the body, leading to a series of diseases, which are usually related to the immune system, such as inflammatory bowel disease Ilc3s is the main regulator of inflammation, infection, microbial composition and metabolism It can interact with neuron cells at discontinuous mucosal sites to initiate mucosal defense mechanism However, at present, researchers do not know how the neuroimmune circuit operates and integrates external environmental signals to regulate ilc3 response at the level of organism 【5】 PNAs: enhancing the anti-inflammatory function of macrophages is expected to treat a variety of human inflammatory diseases doi: 10.1073/pnas.1821601116 recently, an international journal Proceedings of the National Academy of In the Research Report on sciences, scientists from the University of Illinois identified a special molecular switch, which can promote macrophages to clean up the remains of cells due to infection, rather than causing inflammation and tissue damage Macrophages are a kind of special immune cells in the body These cells can produce inflammation, and moderate inflammation is very beneficial, because inflammation signals will bring other immune cells to a special site to eliminate infection However, when the inflammation is out of control, it will cause a series of inflammatory diseases, which will lead to excessive cell and tissue damage, and then cause an irreversible vicious circle When phagocytosis of cell debris or exogenous pathogens promoting inflammation, macrophages play a very important role in reducing the inflammatory response, while macrophages can play a very different role between the two roles The mechanism of switching is not clear to researchers at present Photo source: Thomas Brunner [6] SCI adv and cell death dis: uncover the double-sided role of special transcription factor LRH-1 in the inflammatory process of the body! Doi: 10.1126/sciadv.aav9732 doi: 10.1038/cddis.2017.173 recently, in a research report published in the international journal Science advanced, scientists from the University of Kansas found that LRH-1 protein may play a key role in the immune system of the body, inhibit the function of the protein or effectively help to treat a variety of inflammatory diseases For example, when the intestinal epithelium of the body is damaged, the immune cells can inhibit bacteria If an individual suffers from Crohn's disease, his immune cells will be in a state of continuous activation The researchers found that the transcription factor LRH-1 plays a very important role in the immune cells In fact, many years ago, they studied it Researchers have found the existence of this protein in T cells Now researchers have found that LRH-1 is mainly responsible for ensuring whether the immune defense function of the organism is normal If LRH-1 does not exist, no immune response in the organism will be activated The results of this study are expected to help researchers develop new therapeutic strategies or drugs to control the body damage by inhibiting the function of LRH-1 Immune response to injury 【7】 JCI: new discovery! A special peptide which can simulate the beneficial cholesterol or is expected to reverse inflammatory bowel disease! Doi: 10.1172/jci123700, an International Journal of clinical In the Research Report on investigation, scientists from the University of California found that a special peptide can mimic the function of high-density lipoprotein (HDL), which may help to treat the inflammation related to inflammatory bowel disease (IBD); in the paper, the researchers also revealed the molecular mechanism of the occurrence of inflammatory bowel disease and its therapeutic effect Other possible drugs Inflammatory bowel disease is a chronic inflammatory disease of the digestive tract The most common inflammatory bowel disease includes Crohn's disease and ulcerative colitis At present, there is almost no effective treatment for inflammatory bowel disease, and most of the patients ultimately need surgery Now researchers find that compared with healthy people, the level of apoA-I protein in the body of patients with inflammatory bowel disease is lower, and apoA-I is HDL And apoA-I protein can also slow down the expression of inflammation and play the role of antioxidant in the body to inhibit cell damage 【8】 Cell metal: eliminate damaged mitochondria or slow down the expression of chronic inflammatory diseases doi: 10.1016/j.cmet.2019.03.011 Inflammation is a kind of balanced physiological reaction of the body The body needs inflammation to eliminate foreign invaders and irritants However, excessive inflammatory reaction often damages healthy cells and leads to aging and chronic diseases of the body In order to effectively control inflammation, immune cells will hire a molecular machine called NLRP3 inflammatory body NLRP3 is in a state of inactivation in healthy cells, but When mitochondria in cells are damaged by pressure or exposure to bacterial toxins, the function of NLRP3 is turned on When NLRP3 inflammatory body is stuck in the "function on" position, it will cause a series of chronic inflammatory diseases, including gout, osteoarthritis, fatty liver, Alzheimer's disease and Parkinson's disease Recently, an international journal published in cell In metabolism's report, scientists from the University of California and other institutions found a special method through research, which may help to treat some chronic inflammatory diseases, that is, to eliminate damaged mitochondria before cells activate NLRP3 inflammatory bodies 【9】 Nat metabol: scientists found that the vascular system in the bone is expected to resist the inflammatory disease doi: 10.1038/s42255-018-0016-5 recently, an international journal Nature In the metabolism study, scientists from the University of Erlangen Nuremberg in Germany found a new type of vascular network that can directly connect bone marrow and blood supply in periosteum Although bone is a very hard organ, there are dense vascular networks inside (bone marrow) and outside (covered by periosteum), which is why fractures usually cause severe bleeding However, new blood cells can also enter human body through the vascular system leaving the bone marrow Researcher Anika gr ü neboom said that, like all organs, bones also need closed blood (blood vessels) flow to maintain basic functions When fresh blood is transported to organs through arteries, the vein will also transport "used" blood again At present, researchers have not clarified the precise structure of closed blood vessels in bones 【10】 Nat commun: special metabolites in strawberry and pomegranate may effectively inhibit the progress of inflammatory bowel disease doi: 10.1038/s41467-018-07859-7 recently, a research report published in the international journal Nature communications, from the University of Louisville found that one of the raspberry and pomegranate is urolithin A Uroa's microbial metabolites may help reduce and protect the body against inflammatory bowel disease (IBD) Today, millions of people suffer from inflammatory bowel disease (such as Crohn's disease), but there is no effective treatment for it In this study, the researchers found that