Many articles interpret the new achievements of scientists in the field of stroke!

In this article, the editor sorts out the new achievements that scientists have made in the field of stroke research recently, and we will learn together! Photo source: Ebrahim noroozi [1] The Lancet: the new compound drug preparation is expected to achieve the four in one effect and significantly reduce the risk of heart disease and stroke in the population doi: 10.1016/s0140-6736 (19) 31791-x recently, an international journal was published in the In the Research Report on lancet, scientists from McMaster University in Canada found that a simple combination of four drugs can effectively reduce the risk of heart attack, stroke and heart failure in people, which may be a simple way to effectively inhibit heart problems in people, especially in poor countries The combination of two antihypertensive drugs, a cholesterol drug and aspirin, many people can't afford or insist on taking so many drugs separately, clinicians think the compound drug preparation may help patients; in a previous study in India, researchers found that the combination of the drugs can effectively reduce the cholesterol and aspirin of the population Blood pressure, and this latest study provides stronger evidence as researchers track people for heart disease, stroke and other problems, not just risk factors 【2】 Eating nuts linked with lower risk of fatal heart attack and stroke Recently, scientists from Isfahan Institute of cardiovascular research in Iran said that eating nuts at least twice a week could reduce the risk of death from cardiovascular disease by 17% Researcher noushin Dr mohammadifard said that nuts are a good source of unsaturated fatty acids, and they contain a small amount of saturated fatty acids At the same time, nuts also contain proteins, minerals, vitamins, cellulose, phytosterols and polyphenols that are beneficial to the heart health of the body Studies from Europe and the United States have shown that nuts have a certain protective effect on the body's cardiovascular system, but Research evidence from the eastern Mediterranean is limited 【3】 NEJM: break the rules! The study found that "up" systolic blood pressure and "down" diastolic blood pressure predicted the risk of heart attack or stroke, respectively Doi: 10.1056/nejmoa1803180 a study published in NEJM Journal showed the opposite results compared with previous decades: the "up" systolic blood pressure and "down" diastolic blood pressure in blood pressure readings predicted the risk of heart attack or stroke, respectively Previous studies have shown that high systolic blood pressure is more likely to cause adverse outcomes than diastolic blood pressure "This study provides a lot of data for a basic question, and gives such a clear answer," said lead author Dr Alexander C flint, a part-time researcher in stroke experts and research at Kaiser medical institution "Regardless of how you analyze the data, systolic and diastolic pressures are important "The current retrospective study is" by far the largest of its kind, "says Dr flint He reviewed 36 million ambulatory blood pressure readings conducted by 1.3 million adult members of Kaiser medical institution in Northern California between 2007 and 2016 Systolic blood pressure - the upper limit of blood pressure readings - measures the hardness of the heart pumping blood into the arteries Diastolic pressure - the number at the bottom - is the pressure the heart puts on the arteries when it rests between beats 【4】 Neurology: too low LDL cholesterol may increase the risk of hemorrhagic stroke doi: 10.1212/wnl.0000000000007853 current guidelines recommend lowering cholesterol to reduce the risk of heart disease In a new nine-year study, researchers from China and the United States looked at the relationship between low-density lipoprotein cholesterol (LDL) - commonly known as "bad" cholesterol - and hemorrhagic stroke, and found that if cholesterol falls too low, it may increase the risk of hemorrhagic stroke This type of stroke occurs when blood vessels burst in the brain, the results of which are published in the journal Neurology The researchers found that participants with LDL cholesterol levels below 70 mg / dl had a higher risk of hemorrhagic stroke Xiang Gao, director of the nutrition epidemiology laboratory at Penn State University and associate professor of nutrition science, said the findings may help refine and personalize recommendations for ideal cholesterol target levels As with many things in nutrition, moderation and balance are key in determining the optimal target level of LDL cholesterol, the researchers say You can't go to extremes - too high or too low If you have a higher risk of hemorrhagic stroke due to family history or risk factors such as high blood pressure and heavy drinking, you may need to pay extra attention to LDL cholesterol levels 【5】 SCI Rep: nanoparticles can help treat stroke doi: 10.1038/s41598-019-42633-9 a new study found that small selenium particles can promote the recovery of brain injury and have therapeutic effect on ischemic stroke Pharmacologists, including Alireza mashaghi from Leiden pharmaceutical research academic center, found that selenium nanoparticles can inhibit the molecular mechanism of brain cell loss after stroke The research results were published in scientific reports When an ischemic stroke occurs, the blood vessels that supply the brain contract or block As a result, the blood supply to the brain is inadequate "Lack of blood can lead to brain tissue damage due to cytotoxicity, inflammation and cell death," mashaghi explained This in turn can lead to brain dysfunction and neurological disorders such as numbness, vision problems, dizziness and severe headaches "Ischemic stroke accounts for 87% of all strokes and is an important cause of death So far, no neuroprotective agents have been shown to produce any measurable improvement in the health of stroke patients Now, our results show that selenium nanoparticles can inhibit the molecular mechanism of brain cell loss after stroke Photo source: [6] AJCN: daily intake of eggs or cholesterol does not increase the risk of stroke doi: 10.1093/ajcn/nqz066 recently, a new study from the University of East Finland showed that high concentration of dietary cholesterol or one more egg per day does not lead to an increased risk of stroke The results were published in the American Journal of clinical nutrition The results of earlier studies address the conflicting relationship between dietary cholesterol or egg intake and stroke risk Some studies found a link between high dietary cholesterol intake and increased risk of stroke, while others suggested that egg consumption with high cholesterol content was associated with reduced risk of stroke For most people, dietary cholesterol plays a very small role in affecting serum cholesterol levels In the Kuopio Ischemic heart disease risk factors study, conducted at the University of eastern Finland from 1984 to 1989, researchers assessed the dietary habits of 1950 men between the ages of 42 and 60 who did not have a baseline diagnosis of cardiovascular disease ApoE phenotype data were available for 1015 men who participated in the study Of these, 32% are known carriers of apoE4 【7】 Cell: malavero, a drug that blocks HIV infection, is expected to promote faster recovery of stroke patients Doi: 10.1016/j.cell.2019.01.044 more than 6 million Americans have disabilities after stroke Even a mild stroke can leave survivors with weak arms and legs, poor muscle control and memory loss Now, in a new study, researchers from the University of California, Los Angeles, found that people who were born without the CCR5 gene recovered better from mild strokes than those who were born with the CCR5 gene The findings, published in the journal Cell, may lead to the development of the first drug to reverse the physical and mental effects of a mild stroke The researchers say this is the first time a human gene has been linked to better recovery from a stroke Our findings offer exciting potential for improving patients' health and quality of life " CCR5 plays multiple roles in the body For HIV, the gene is the gateway that the virus must invade in order to infect the immune system 【8】 Stop losing weight! The study found that obesity has a higher survival rate after stroke! Being overweight may be linked to better life from stroke It may sound strange, but a study released at the 71st annual meeting of the American Society of Neurology shows that some extra fat may increase the survival rate of stroke patients Medical experts call this phenomenon the obesity paradox, referring to a medical theory: obesity has a protective effect on some people, such as the elderly with large age or suffering from some chronic diseases Sick patients At first, researchers found that carrying some extra fat is actually good for people with kidney disease or heart disease, so we think it is necessary to study whether fat is good for the survival of stroke patients The study looked at 1033 patients with an average age of 71 years with acute ischemic stroke The researchers calculated the patient's body mass index (BMI), a measure of a person's body size based on his height and weight If his BMI is between 25 and 29, he is overweight If his BMI is more than 29, he is obese The average BMI of these participants is 27.5 According to BMI, participants were divided into five groups: underweight, normal, overweight, obese and severely obese Then the researchers observed these patients for three months and recorded their physical and disease conditions 【9】 Note to workaholics: working long hours increases the risk of stroke! Go home on time! Working long hours increases your chance of having a stroke in OECD countries, Australia ranks in the last third of working hours, and 13% of people work more than 50 hours a week with pay Working long hours is harmful to our health A new study in France has found that working long hours, often 10 hours or more a day, increases our risk of stroke Other studies have found that employees who work long hours have poor mental health and poor sleep quality Working too long also increases the likelihood of smoking, drinking and gaining weight Regular long hours work has a wide range of effects on our health A new French study of more than 143000 participants found that people who worked more than 10 hours a day and at least 50 days a year had a 29% higher risk of stroke There was no difference between men and women, but it was more pronounced among white-collar workers under the age of 50 【10】 Clin Nutr: absolutely! More evidence that fried food increases the risk of heart disease and stroke! Doi: 10.1016/j.clnu.2019.05.008 go to the market in any city and look at the menu -- corn hot dog, fried Oreo, even fried butter -- you will soon find that Americans like fried food But another study shows that it's time to put down the corn hotdog Eating fried foods increases the risk of heart attack and stroke, the study found The more fried food you eat, the greater your risk The results of this study were recently published in the Journal of clinical nutrition