Many articles interpret the new achievements of dementia research!

Nowadays, dementia is one of the most important social and health crises facing human beings in the 21st century In recent years, scientists have carried out a lot of research to analyze the pathogenesis of dementia and develop new preventive or therapeutic strategies In this paper, the editor will sort out the relevant research results and share them with you! Image source: en.wikipedia.org [1] SCI transal Med: even with a single head injury, there will be tau protein tangles related to dementia in human brain doi: 10.1126/scitranslmed.aaw 1993 In a new study, researchers from Imperial College, University of London, UK and other research institutions for the first time visually observed the protein "tangle" related to dementia in the brain of patients suffering from a single head injury, and the relevant research results were published in the journal Science Translational Medicine In an early study, the researchers looked at 21 patients who suffered moderate to severe head injuries (mainly from traffic accidents) at least 18 years ago, and 11 healthy people who did not suffer head injuries The study showed that some of these patients had protein clumps in their brains called tau protein tangles; the researchers recruited patients from the Institute of health and welfare at the University of Glasgow and the Imperial College of technology's NHS trust for health care They said the new study could speed up the development of ways to degrade tau tangles by allowing medical staff to monitor tau protein levels 【2】 Ijgp: migraine or closely related to high-risk dementia doi: 10.1002/gps.5180 recently, an International Journal of geriatric psychology was published with the title of "migrate and the risk of all ‐ cause demantia, Alzheimer's disease, and vascular demantia: a prospective cohort study in community ‐ dwelling older In their study, scientists from the University of Waterloo found that migraines are either closely related to high-risk dementia Dementia is the most common neurological disease in the elderly, and headache, including migraine, is the most common neurological disease in all age groups In this study, researchers studied 679 community residents aged 65 and above, who showed that migraine is an important risk factor for dementia in the population, including Alzheimer's disease And so on Identifying middle-aged risk factors for dementia, such as migraine, may help researchers identify individuals at risk early and improve scientists' understanding of the molecular mechanisms underlying Alzheimer's and dementia 【3】 JAMA network open: Alert! Prostate cancer hormone therapy may increase the risk of Alzheimer's disease and dementia doi: 10.1001/jamanetworkopen.2019.6562 recently, an international journal JAMA network In the study report on open, scientists from the school of medicine of Pennsylvania State University found that for prostate cancer patients, patients treated with androgen deprivation therapy were more likely to be diagnosed with Alzheimer's disease or dementia than those who did not In this study, a sample of 154098 men from the team of researchers was analyzed 62330 of them received ADT within two years of being diagnosed with prostate cancer, while the other 91759 did not receive ADT Of the patients who received hormone therapy, 13% were later diagnosed with Alzheimer's disease, while 9% of the patients who did not receive treatment People who were later diagnosed with Alzheimer's disease, and for dementia, these numbers may also increase, i.e., 22% of prostate cancer patients who received ADT were later diagnosed with dementia, while 16% of those who did not receive ADT were diagnosed with dementia For dementia, the results of this study are based on a small-scale study conducted by previous researchers, who have found that hormone therapy can cause brain cognitive risk in prostate cancer patients According to Framingham heart research data, for men, the risk of Alzheimer's disease in their lifetime is 12% 【4】 JAMA Neurol: the new pet staging system can monitor Alzheimer's disease doi: 10.1001/jamanuerol.2019.2214 according to an online study recently published in JAMA neurology, the researchers found that the staging system of β - amyloid protein (a β) accumulation may be useful for patients monitoring the whole course of Alzheimer's disease (AD) Niklas Mattsson, M.D., of Lund University in Sweden, and colleagues used data from 741 people to construct a longitudinal and effective in vivo staging system of AD through amyloid positron emission tomography (PET): 304 of them had no cognitive impairment, 384 had mild cognitive impairment and 53 had ad dementia The early, middle and late regions of a β accumulation were determined by using CSF a β 42 and F 18 labeled florbetapir data 【5】 Front aging Neurosci: Alzheimer's disease can be "latent" for 34 years doi: 10.3389/fnagi.2019.00074 Alzheimer's disease, that is, Alzheimer's disease According to China's disease burden report, in the past 11 years, from the change of death number, Alzheimer's disease increased by 57.8%, ranking fifth in all diseases According to a recent study in the United States, a person's brain changes 34 years before he has symptoms of Alzheimer's disease Research shows that a person with Alzheimer's disease symptoms 11 to 15 years before the occurrence of signs of cognitive impairment, these small changes can be seen in the cognitive test Imaging examination also found that the medial temporal lobe changed in the first three to nine years before the symptoms appeared, while the medial temporal lobe was related to memory Cerebrospinal fluid detection showed that the tau protein level of patients with Alzheimer's disease had increased 34 years ago; the modified tau protein "p-tau" level increased 13 years before the symptoms appeared Photo source: Imperial College London [6] can Mediterranean diet and exercise really reduce the risk of dementia? News reading: could a Mediterranean diet and exercise reduce demantia risk? Scientists from the University of East Anglia have launched a new study to see if Mediterranean diet and exercise can improve brain function and reduce the risk of dementia The Mediterranean diet is rich in fruits, vegetables, nuts, beans, whole grains, fish and olive oil, as well as a limited amount of dairy products, red meat and sweets Red wine is a typical alcoholic beverage This study is the first one launched in the UK to try to change people's diet and exercise habits within 24 weeks Researchers tracked more than 60 participants recruited from Newcastle and Birmingham, Anne Marie Professor minihane said that there are currently about 850000 dementia patients in the UK, and the number of patients will exceed 2 million by 2050; there are currently drugs that can help improve the symptoms of patients, such as Alzheimer's disease, the most common dementia, but no treatment can block or slow the spread of disease through the brain 【7】 SCI adv: brushing helps prevent Alzheimer's disease doi: 10.1126/sciadv.aau3333 researchers at Bergen University found that there is a clear link between gum disease and Alzheimer's disease, so brushing not only helps maintain good oral health, prevent tooth decay, but also helps prevent Alzheimer's disease The researchers found DNA based evidence that bacteria that cause gingivitis can move from the mouth to the brain Proteins produced by bacteria can damage nerve cells in the brain, leading to memory loss and eventually Alzheimer's disease Mydel points out that bacteria do not cause Alzheimer's disease alone, but the presence of these bacteria can greatly increase the risk of developing the disease and lead to faster disease progression The good news, however, is that this study shows that you can do something to slow down Alzheimer's 【8】 Alzhe Dement: brain healthy diet may reduce the risk of dementia in the population doi:10.1016/j.jalz.2018.12.011 recently, an international magazine published in Alzheimer's& In the Research Report on dementia, scientists from the University of New South Wales found that when people follow a diet that improves brain health, their risk of cognitive impairment will be reduced; the researchers believe that long-term adherence to a diet that increases brain health seems to reduce individual cognitive impairment And related diseases, including Alzheimer's disease and dementia In this paper, the researchers analyzed the "minderanean dash intervention for neurodegenerative delay" Diete, Mediterranean - Deshu intervention neurodegenerative delayed diet) is a potential protective effect Mediterranean diet is considered to have some protective effects on other health aspects, such as cardiovascular disease; the component of mind diet is based on Mediterranean diet, and additionally added food related to brain health This diet is mainly composed of 15 recipes, with emphasis on green Leafy vegetables, whole grains, olive oil and a small amount of red meat 【9】 Nat Med: scientists have identified the new dementia risk gene doi: 10.1038/s41591-018-0223-3 Recently, in a research report published in the international journal Nature Medicine, researchers from the University of California have identified the genetics of neurodegenerative diseases in dementia patients through research Process, relevant research results may help researchers develop new therapies to slow or inhibit the progress of disease In this paper, the researchers found two kinds of genes involved in the mutation, which will lead to the overexpression of tau protein, which is a sign of the progressive loss of neurons in the body of dementia patients Although this study is conducted on the model of dementia mice, the researchers also conducted additional tests to show that the same genetic process will occur in the human brain The researchers searched a large database of genetic effects of experimental drugs to determine which drugs can change the occurrence of neuron loss or neurodegeneration; in human cell culture medium, the researchers found that using these molecules can interfere with the neurodegenerative process of the body 【10】 Am J Epidemiol: the impact of dementia on people is also divided into men and women? Doi: 10.1093/aje/kwz048 dementia is one of the biggest causes of death in Australia, but researchers from the University of Queensland (UQ) found that dementia has different effects on men and women Dr Michael Waller, a health biostatistician at UQ, said the study, carried out in collaboration with the Florey Institute of neuroscience and mental health, analyzed data from 1.1 million people in Australia who died of dementia "As people age, the risk of dementia increases significantly, especially in people over 80." Waller said "Our study analyzed records of dementia related deaths In 184562 studies, we found that women were 14% more likely to die of Alzheimer's than men Alzheimer's can cause dementia by destroying neurons in the brain " The study also found that men died of vascular disease