Many articles focus on the new development of insomnia research!

According to some data, about 25% of the world's people have experienced insomnia, about 20-30% of which are caused by different sleep disorders, while the proportion of developed countries and cities may be higher In recent years, scientists have done a lot of research in the field of human insomnia, and also made a lot of gratifying results In this paper, the editor will sort out the relevant research results and share them with you! Photo source: Wikipedia [1] NAT Genet: a major breakthrough! More than 1.3 million people's Congress data help reveal hundreds of genes related to insomnia doi: 10.1038/s41588-018-0333-3 insomnia is the second most popular mental disease in the world, but there is no effective treatment at present Although a large number of studies have shown that insomnia can be inherited, scientists have not yet fully understood the genes and neurobiological pathways behind it In order to reveal these secrets, researchers from Amsterdam Free University and Netherlands Institute of neuroscience recently conducted a large-scale study They analyzed 1331010 genetically related human tissue samples to detect new gene loci related to insomnia, and further studied related signal pathways, cells and tissues Relevant research results were recently published in nature In genetics magazine Through gene mapping, quantitative trait loci analysis and chromatogram, the researchers found that 202 loci involving 956 genes were related to insomnia, and meta-analysis revealed a difference of 2.6% The researchers found a large number of related genes in the axon part, cortex and subcortical tissues of neurons, as well as in specific cell types (including striatum, hypothalamus and screen body neurons) The researchers also found a strong genetic link between psychiatric characteristics and sleep time, but a link with other sleep related characteristics 【2】 Jcsm: the occurrence of insomnia in the elderly caused by nocturnal light note doi: 10.5664/jcsm.7490 a new population-based survey results show that there is a significant correlation between nocturnal artificial outdoor light and insomnia The results showed that the increase of light exposure at night was related to the increase of hypnotic prescription and daily dose intake In addition, older people exposed to higher levels of artificial outdoor light at night will use hypnotics in longer or higher daily doses "This study observed a significant association between outdoor, artificial, and nighttime lighting intensity and the prevalence of insomnia." "Our findings support this theory," said Kyoung Bok min, PhD, associate professor of occupational and environmental medicine at the school of medicine, Seoul National University, South Korea According to the American Society of sleep medicine, insomnia may involve difficulties in falling asleep, staying asleep or waking up too early Various environmental factors, including excessive noise or light and extreme temperature, can disturb most people's sleep 【3】 Mol psych: insomnia often? Maybe it's your genes! Doi: 10.1038/s41380-018-0033-5 recently, in a research report published in the international journal Molecular psychology, scientists from the University of California, San Diego and the San Diego health care system discovered special genes that can induce sleep problems, and related research clarified insomnia and mental diseases such as depression (or type 2 diabetes) And other diseases) 20% to 50% of American veterans have sleep problems, and the effect of insomnia on their health is often terrible, which brings great pressure to the whole medical system; chronic insomnia is often closely related to a variety of health problems, such as heart disease and type 2 diabetes , mental diseases (such as post-traumatic stress disorder and suicide); two previous studies have shown that the characteristics of various sleep related problems, including insomnia, have certain heritability Based on these findings, researchers began to consult about specific gene mutations affecting individual sleep 【4】 The lancet Neurol: insomnia pay attention! Maybe it's a sign of Parkinson's disease! doi：10.1016/S1474-4422(17)30173-4 Insomnia may be an early sign of brain related diseases Recently, researchers from the University of Aarhus conducted a case-control study on patients with rapid eye movement sleep behavior disorder (RBD), in-depth study of the cells involved in the patients' brain immune system and the related behaviors of neural cells in the brain that produce dobutamine The research results are published in the international journal The Lancet Neurology The study found that patients suffering from REM sleep behavior disorder may have the risk of Parkinson's disease or dementia in the future, because these patients lack dopamine in the brain, because the brain cells that produce dopamine stop working, which will cause Parkinson's disease The main feature of REM sleep behavior disorder is that patients' sleep will be disturbed, they will often dream; in the sleep process, healthy people will be very relaxed, while patients suffering from REM sleep behavior disorder will continue to have abnormal behaviors, such as beating, kicking, etc Photo source: Wikipedia [5] NAT Genet: breakthrough! Scientists first identified 7 risk genes for insomnia doi: 10.1038/ng.3888, published in the international journal Nature In the Research Report on genetics, researchers from the University of Amsterdam and other institutions found seven risk genes related to insomnia for the first time through research, which may provide ideas for researchers to clarify the biological mechanism of inducing human insomnia; in addition, the researchers also said that insomnia may not be a pure psychological disease as people often say Insomnia is perhaps the most common health complaint we face in our daily life Even after treatment, sleep deprivation has been bothering people's health In this study, researchers found risk genes related to insomnia, which is very important to reveal the causes of insomnia According to researcher van someren, this study is to understand insomnia at the level of "communication" between neurons We hope to develop a new treatment for insomnia later 【6】 Scientists have found the root cause of insomnia! An international research team has found seven risk genes for insomnia for the first time With this finding, researchers have taken an important step to remove the biological mechanism that leads to insomnia In addition, this discovery proves that insomnia is not as usual, purely psychological state Today, Nature Genetics published the results of this study Insomnia is probably the most common health problem Even after treatment, poor sleep is a persistent weakness for many people By identifying risk genes, Professor Danielle posthuma (VU and VUmc) and EUS van someren (Netherlands Institute of neuroscience, VU and VUmc), the lead researchers of this international project, have come closer to uncovering the biological mechanism of insomnia tendency Professor van someren, who specializes in sleep and insomnia, believes that these findings are a way to begin to understand insomnia at the level of communication within and between neurons, so as to find new treatments 【7】 New medicine for insomnia! Eisai and Purdue Pharma present efficiency and safety data from second pivotal phase 3 study at the sleep research society's conference: advanced in sleep and circular Science Pharma recently released the six-month efficacy and safety data of the long-term phase III clinical study of lemborexant in the treatment of insomnia (a kind of wakefulness rhythm disorder) The study is a global, multicenter, randomized, controlled, double-blind, parallel group study, involving 949 adults (18-88 years old) with insomnia, of which about 28% are aged 65 or above This study evaluated the efficacy and safety of lemborexant compared to placebo In the first six months of the study, patients were randomly divided into three groups, receiving 5 mg of lamborexant, 10 mg of lamborexant and placebo The primary and key secondary efficacy goals of the study were evaluated using patient self-report using an electronic sleep diary 【8】 Recently, the innovative insomnia drug seltoroxant reached the clinical end point of phase 2B Minerva neurosciences announced that seltoroxant (min-202), jointly developed by the company and Janssen, is in phase 2B clinical trial for insomnia patients To achieve the primary and critical secondary end points of the trial, significantly accelerate the sleep time of insomnia patients, and reduce the wake-up time of patients after falling asleep According to the American Academy of sleep medicine, 30-35% of adults have short-term insomnia symptoms, while 10% of adults have chronic insomnia (defined as insomnia at least three times a week for at least three months) Chronic insomnia has a negative effect on health Insomnia patients often have other mental diseases at the same time, such as depression and anxiety The incidence rate of insomnia is higher among women and elderly people Insomnia is especially serious for the elderly over 65 years old, and has important correlation with incidence rate and mortality rate of the elderly (Bio Valley bio Com) Bio Valley more wonderful inventory! 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