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    Home > Active Ingredient News > Study of Nervous System > Management of acute ischemic stroke during anticoagulation of atrial fibrillation

    Management of acute ischemic stroke during anticoagulation of atrial fibrillation

    • Last Update: 2022-09-30
    • Source: Internet
    • Author: User
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    Acute ischemic stroke (CIS) has surpassed cardiovascular disease and malignant tumors in China and become the first cause of
    death.


    Intravenous thrombolytic therapy

    According to the 2018 US CIS Early Management Guidelines:

    (1) For patients with ischemic stroke symptoms within 3 to 4.


    (2) For patients with oral warfarin within 3~4.


    (3) rt-P A intravenous thrombolysis is not recommended for direct thrombin inhibitors or direct Xa factor inhibition

    Patients with the agent, unless the patient's laboratory indicators such as activated partial thromboplastin time, INR, platelet count, snake venous enzyme agglutination time (ECT), prothrombin time, and direct Xa activity test are normal or the last dose has been taken for more than 48 hours and the renal metabolism function is normal

    The timing of restart anticoagulation therapy

    The timing
    of initiation of anticoagulation should be selected based on the patient's NIHSS score and assessment of bleeding risk.


    Treatment in patients with bleeding or anticoagulation contraindications

    Patients with postinfarct bleeding should be postponed to 4 to 8 weeks
    after onset of illness, as long as bleeding and related risk factors can be treated, depending on the patient's specific circumstances.


    New oral anticoagulation

    Studies have shown that the use of novel oral anticoagulants for secondary prevention of stroke reduces the risk of stroke or systemic embolization recurrence by up to 16%, the risk of disabling or fatal stroke by 19%, and significantly reduces the risk of intracranial hemorrhage by up to 80%
    compared with well-controlled warfarin.


    epilogue

    In summary, the proportion of acute ischemic stroke due to atrial fibrillation has been on the rise in recent years, and clinicians should attach great importance to the management of
    such patients.


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