Magic marijuana! Cannabinoid in the treatment of obstructive sleep apnea (OSA) into phase II clinical

June 8, 2018 / BIOON / -- therapix Biosciences is a clinical stage biopharmaceutical company focusing on the development of cannabinoids in Israel Recently, the company announced the evaluation of cannabinoid product thx-110 in the treatment of obstructive sleep apnea (OSA) phase IIa clinical study has entered the first group of patients The study is a one arm, open label, concept validation study, with a planned cohort of 30 patients In the study, patients took thx-101 orally once a day and were followed up for one month The main efficacy end point was to evaluate the significant change of apnea hypopnea index (AHI), an index to evaluate the severity of sleep apnea The purpose of this study was to demonstrate the safety, tolerability, and efficacy of thx-101 therapy, and to assess the performance of the drug in adult OSA patients According to the American Academy of sleep medicine (AASM), about 12% of American adults suffer from OSA In the United States alone, the economic burden of undiagnosed sleep apnea is close to $150 billion a year Thx-110 is a combination drug, which is composed of dronabinol (THC) and palmitoyl alcohol (PEA) THC is a kind of psychoactive molecule in cannabis plant The compounds such as synthetic thc are used to treat a wide range of medical diseases, such as reducing pain, anti-inflammatory, reducing or preventing nausea These drugs are also used in cancer patients receiving chemotherapy or patients with mental health disorders Pea is naturally found in a variety of foods, such as egg yolks, soybeans and milk In some parts of Europe, pea derivatives (such as normast and pelvilen) have been used for special purpose food sales In April 2015, Health Canada added pea to the natural health products list, a category of health products that includes vitamins, mineral supplements, herbal preparations, traditional or homeopathic therapies, probiotics and enzymes Preclinical studies have shown that the combination of THC and pea has been shown to produce a better "follow-up effect" than the use of THC or pea alone Pea belongs to the family of endogenous cannabinoids, which is considered to have analgesic or anti-inflammatory effects The combination of pea and thc can stimulate cannabinoid receptor, inhibit metabolism degradation and increase thc uptake Source: treating objective sleep apnea using cannabinoid based drugs