M systems: high fat and high protein diet aggravates Clostridium difficile infection

February 12, 2020 / BIOON / -- recently, in a new study published in the Journal of M systems, researchers reported that mice fed a high protein, high-fat diet were more likely to develop fatal Clostridium difficile infection than those in the control group Their findings also show that a high carbohydrate diet can prevent these infections According to the Centers for Disease Control and prevention, hundreds of thousands of people are diagnosed with C difficile infection every year in the United States, and more than 10000 people die Taking antibiotics increases the risk of infection in the population Since their research was conducted in mice, further research is needed to establish a link between these diets and human infection, the researchers warned In the study, researchers from the University of Nevada and other institutions divided the mice into four groups for testing Each group of mice received antibiotic treatment, but at the same time they received a different diet: the first group of mice received a high-fat, high protein diet, the second group of mice was a high-fat, low protein food; the third group of mice was a high carbohydrate diet; the fourth was the standard laboratory diet of experimental mice The results were astonishing In the high protein, high fat group, all animals were seriously infected and died within 4 days In the high-fat, low protein group, only 2 animals died In the high carbohydrate group, 2 mice showed mild symptoms and recovered; in the standard diet group, all animals showed signs of infection, but also recovered Recent studies have shown that antibiotics can cause extensive killing and killing of intestinal microorganisms, so that resistant Clostridium difficile can reproduce in large numbers The new study suggests that diet may increase the damage of antibiotics to intestinal microflora, resulting in the growth of Clostridium difficile and disease Sources of information: clostridioids diverse information flows with a high-protection, high fat diet original sources: chrisabelle C meffered et al A high fat / high protein, Atkins type diet exists clostridioids (Clostridium) discrete infection in rice, where as a high carbohydrate diet protection Mssystems Feb 2020, 5 (1) e00765-19; DOI: 10.1128/mSystems.00765-19