Lupus occurs in these situations, the guide teaches you to deal with it properly!

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with complex etiologies related to genetics, sex hormones, and environment (eg, viral and bacterial infections) [1-3].

What to do when lupus encounters these situations? Guidelines indicate the direction of
treatment.

All patients with SLE should be screened for an-tiphospholipid antibodies (aPL).

Patients with SLE with high-risk aPL may be considered for primary prophylaxis of thrombosis with antiplatelet agents, particularly if other atherosclerosis/thrombophilic factors are combined, after weighing the risk of bleeding.

If thrombosis or morbid pregnancy has occurred, the principles of treatment are consistent with
primary antiphospholipid syndrome (APS).

Risk assessment of patients with SLE for infection is required for risk factors for the following infections: older age/frailty, diabetes mellitus, renal involvement, immunosuppressant or biologic therapy, and use of hormones
.

Prophylaxis is recommended to prevent infection, including vaccines, and to identify and treat infection
as early as possible.

Patients with SLE should be regularly assessed for traditional disease-associated cardiovascular risk factors, including persistent disease activity, long course of disease, moderate/high/low aPL, renal involvement (particularly persistent proteinuria and/or glomerular filtration rate <60 ml/min), and long-term use of corticosteroids
.

Based on individualized risk stratification, low-dose aspirin and/or lipid-lowering agents may be used for cardiovascular disease prophylaxis
in patients with SLE.

How are glucocorticoids used to treat patients with SLE?

How should patients be treated when they have organ and system involvement?

Where can I find more guidelines for the diagnosis and treatment of common rheumatology diseases?

Open the Decision Assistant App Clinical Guidelines module

Search for the name of the disease you want to know and talk to authoritative guides at home and abroad! 👇

Download the Decision Assistant App, the guide is free at any time~

Resources:

[1] Durcan L，O'Dwyer T，Petri M.
Management strategies and future directions for systemic lupus erythematosus in adults[J].
Lancet，2019，393（10188）:2332‐2343.
DOI:10.
1016/S0140‐6736（19）30237‐5.

[2] Fava A，Petri M.
Systemic lupus erythematosus:diagnosis and clinical management[J].
J Autoimmun，2019，96:1‐13.
DOI:10.
1016/j.
jaut.
2018.
11.
001.

[3] Lisnevskaia L，Murphy G，Isenberg D.
Systemic lupus erythematosus[J].
Lancet，2014，384（9957）:1878‐1888.
DOI:10.
1016/S0140‐6736（14）60128‐8.

[4] The road to achieving the standard of systemic lupus erythematosus: interpretation of the 2019 European Union Against Rheumatism Guidelines for the Management of Systemic Lupus Erythematosus.

▼▼▼Click to read the original article to download the App